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Synthesis and Evaluation of Novel Quinazolinone-1,2,3-Triazoles As Inhibitors of Lipoxygenase Publisher



Farjadmand F1, 2 ; Arshadi H3 ; Moghimi S4 ; Nadri H5 ; Moradi A5 ; Eghtedari M6 ; Jafarpour F3 ; Mahdavi M4 ; Shafiee A4 ; Foroumadi A4, 7
Authors
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Authors Affiliations
  1. 1. Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Food and Drug Organization, Ministry of Health and Medical Education of Iran, Tehran, Iran
  3. 3. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. 6. Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
  7. 7. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Chemical Research Published:2016


Abstract

This work reports the successful synthesis of quinazolinones carrying triazole derivatives with potent lipoxygenase inhibitory activities. This protocol involves sequential reactions affording novel products in high yields without the need for a tedious work-up procedure.