Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation Publisher

Izadifard M¹ ; Ahmadvand M² ; Alimoghadam K² ; Pashaiefar H¹ ; Seghatoleslami G³ ; Barkhordar M² ; Yaghmaie M¹

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1. Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology, and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran
3. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Gene Reports Published:2024

Abstract

Acute graft-versus-host disease (aGVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), a procedure intended to treat malignant and nonmalignant hematological illnesses. At this time, there are no laboratory tests that can accurately forecast the likelihood of developing aGVHD, a patient's response to treatment, or their chance of life. Encouragingly, specific microRNAs have demonstrated consistent connections with the onset, severity, and clinical consequences of aGVHD through their dysregulated expression patterns, providing potential advantages in patient management and individualized therapy plans. Additionally, minimally invasive diagnostic methods are made easier by identification and measurement of circulating microRNAs as biomarkers in bodily fluids such as blood or urine using high-throughput screening techniques like qPCR, microarray analysis, and next-generation sequencing. Regarding the diagnosis, prognosis, and therapeutic response, this review is concentrated on the most recent research that offer proof of the possible utility of circulating microRNAs in blood and other bodily fluids as minimally invasive biomarkers of aGVHD. In addition to being useful tools for enhancing aGVHD management and patient outcomes, microRNAs distinctive expression patterns and functions in disease biology also present prospects for personalized medicine. © 2024 Elsevier Inc.

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Experts (# of related papers)

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Mohammad Ahmadvand (4)

Marjan Yaghmaie (4)

Style	Citing Format
MLA	Izadifard M, et al.. "Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation." Gene Reports, vol. 37, no. , 2024, pp. -.
APA	Izadifard M, Ahmadvand M, Alimoghadam K, Pashaiefar H, Seghatoleslami G, Barkhordar M, Yaghmaie M (2024). Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation. Gene Reports, 37(), -.
Chicago	Izadifard M, Ahmadvand M, Alimoghadam K, Pashaiefar H, Seghatoleslami G, Barkhordar M, Yaghmaie M. "Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation." Gene Reports 37, no. (2024): -.
Harvard	Izadifard M et al. (2024) 'Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation', Gene Reports, 37(), pp. -.
Vancouver	Izadifard M, Ahmadvand M, Alimoghadam K, Pashaiefar H, Seghatoleslami G, Barkhordar M, et al.. Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation. Gene Reports. 2024;37():-.
BibTex	@article{ author = {Izadifard M and Ahmadvand M and Alimoghadam K and Pashaiefar H and Seghatoleslami G and Barkhordar M and Yaghmaie M}, title = {Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation}, journal = {Gene Reports}, volume = {37}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Izadifard M AU - Ahmadvand M AU - Alimoghadam K AU - Pashaiefar H AU - Seghatoleslami G AU - Barkhordar M AU - Yaghmaie M TI - Circulating Micrornas As the Achilles Forte of Diagnostics and Prognostics in Acute Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation JO - Gene Reports VL - 37 IS - SP - EP - PY - 2024 ER -

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