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Evaluation of Physical, Mechanical and Biological Properties of Β-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nano Composite Scaffold for Bone Tissue Engineering Application Publisher



Shahi S1 ; Karbasi S2 ; Ahmadi T1 ; Naeimi F3 ; Goodarzi V4 ; Ebrahimibarough S5
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Shahreza Branch, Islamic Azad University, Shahreza, Isfahan, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Advanced Materials Research Center, Materials Engineering Department, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  4. 4. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Materials Technology Published:2021


Abstract

Design of a scaffold with convenient mechanical properties to emulate bone structure is a major challenge for bone tissue engineers. In this study, porous ceramic scaffolds containing various weight fractions of nano β-tricalcium phosphate (nβ-TCP) (with a particle size of about 50-70 nm) were prepared by the replication method. Synthesised scaffolds were then coated with poly(3‐hydroxybutyrate) (PHB) for 30 and 60 sec. According to the morphological and mechanical tests, it was determined that synthesised scaffold containing 50 wt.% of nβ-TCP with a coating time of 30 sec showed desirable properties in bone tissue engineering. The bioactivity of this scaffold indicated that the bone-like apatite layers were well formed on the nanocomposite scaffold. Cell culture study showed a significant increase in cell proliferation between the coated, uncoated and control sample after 5 days of cell culturing. The results confirm that this nanocomposite scaffold has good potential for bone tissue engineering applications. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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