Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
In Vitro Anti-Toxoplasma Gondii Activity of Ganoderma Lucidum Extracts Publisher Pubmed



Ahmadi M1 ; Salimi M2 ; Saraei M3, 4 ; Nezhad NS5 ; Javadi A6 ; Mohammadi F3, 4 ; Heydarian P3, 4 ; Ali E7 ; Hajialilo E3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
  2. 2. Department of medical parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  4. 4. Department of Parasitology and Mycology, Qazvin University of Medical Sciences, Qazvin, Iran
  5. 5. Department of medicine Biotechnology, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  6. 6. Department of Community Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  7. 7. Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Iran

Source: BMC Research Notes Published:2023


Abstract

Objective: Ganoderma extracts have the potential to be used as anti-cancer, anti-inflammatory, immunomodulator, and antimicrobial agents, as evaluated in numerous studies. This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma lucidum on Toxoplasma gondii RH strain tachyzoites, in vitro. Results: All three types of extracts showed toxoplasmacidal effects. The highest percentage of mortality was related to hydroalcoholic extract. The EC50 of Ganoderma extracts for tachyzoites were 76.32, 3.274, and 40.18 for aqueous, hydroalcoholic and alcoholic extracts, respectively. The selectivity index obtained for hydroalcoholic extract was 71.22, showing the highest activity compared to other extracts. According to our findings, the hydroalcoholic part was the most effective substance among the extracts. This basic study showed obvious anti-toxoplasma effect of Ganoderma lucidum extracts. These extracts can be used as candidates for further in-depth and comprehensive studies especially In vivo experiments to prevent toxoplasmosis. © 2023, The Author(s).
Related Docs
1. In Vitro and in Vivo Anti-Toxoplasma Activities of Dracocephalum Kotschyi Extract in Experimental Models of Acute Toxoplasmosis, Acta Parasitologica (2022)
2. Are Viruses and Parasites Linked to Celiac Disease? a Question That Still Has No Definite Answer, Current Pharmaceutical Biotechnology (2019)
3. Prevalence of Toxoplasmosis in Natural Ungulates As Human Zoonotic Meat-Borne Pathogens: A Systematic Review and Meta-Analysis, Journal of Food Science (2025)
4. Overview of Apoptosis, Autophagy, and Inflammatory Processes in Toxoplasma Gondii Infected Cells, Pathogens (2023)
5. Toxoplasma Gondii Vaccine Candidates: A Concise Review, Irish Journal of Medical Science (2023)
6. Serological Survey of Neospora Caninum and Toxoplasma Gondii Co-Infection in Rodents in Northwestern Iran, Iranian Journal of Parasitology (2020)
Experts (# of related papers)
Mahdi Mohebali (1)
Saeedeh Shojaee (1)