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Solubility of Mesalazine in {1-Propanol/Water} Mixtures at Different Temperatures Publisher



Mazaher Haji Agha E1 ; Barzegarjalali M2 ; Adibkia K2 ; Hemmati S1 ; Kuentz M3 ; Martinez F4 ; Jouyban A5, 6
Authors
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Authors Affiliations
  1. 1. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstr. 30, Muttenz, 4132, Switzerland
  4. 4. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia – Sede Bogota, Cra. 30 No. 45-03, Bogota, D.C., Colombia
  5. 5. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

Mesalazine solubility is important to study in solvent mixtures for chemical and pharmaceutical engineering. Therefore, solubility of the drug was determined in water/1-propanol mixtures at T = (293.2 to 313.2) K. To represent the solid-liquid equilibrium for these systems, the van't Hoff, Apelblat, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), modified Wilson, Jouyban-Acree, Jouyban-Acree-van't Hoff, Wilson, NRTL and UNIQUAC models were employed. The thermodynamic quantities of dissolution and mixing were calculated for mesalazine in aqueous 1-propanol solutions at harmonic temperature. Further, calculations of inverse Kirkwood-Buff integrals show that this drug is preferentially solvated by water in all the mixtures, with exception of x1 = 0.20, at 298.2 K. © 2020 Elsevier B.V.
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