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Mesalazine Solubility in Propylene Glycol and Water Mixtures at Various Temperatures Using a Laser Monitoring Technique Publisher



Jouybangharamaleki V1, 2 ; Rahimpour E3, 4 ; Hemmati S5 ; Martinez F6 ; Jouyban A2, 7
Authors
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Authors Affiliations
  1. 1. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogota, Cra. 30 No. 45-03, Bogota, D.C., Colombia
  7. 7. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

An updated lab-made setup is used to study mesalazine solubilization behavior in the binary mixtures of propylene glycol and water at the temperature range of 293.2–313.2 K. The solubility data are correlated with some linear and non-linear cosolvency models including the van't Hoff, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the modified Wilson models, and the mean relative deviations (MRD%) of the predicted solubility data by the investigated models are computed. Furthermore, the apparent thermodynamics of mesalazine dissolution process is calculated by using the van't Hoff and Gibbs equations. Moreover, by using the inverse Kirkwood-Buff integrals it is apparently observed that no preferential solvation of mesalazine is present in these mixtures. © 2018 Elsevier B.V.
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