Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Solubility and Thermodynamic Properties of Mesalazine in {2-Propanol + Water} Mixtures at Various Temperatures Publisher



Mazaher Haji Agha E1 ; Barzegarjalali M2 ; Adibkia K2 ; Hemmati S1 ; Martinez F3 ; Jouyban A4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia – Sede Bogota, Cra. 30 No. 45-03, Bogota, D.C., Colombia
  4. 4. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

The solubility of mesalazine in presence of 2-propanol as cosolvent in aqueous media was reported at T = (293.2 to 313.2) K. It was observed that the solubility of mesalazine is maximal in the 0.4 weight fraction of 2-propanol in the binary solvents. The performances of mathematical models of Jouyban-Acree, Apelblat-Jouyban-Acree, Jouyban-Acree-van't Hoff, modified Wilson, combined nearly ideal binary solvent/Redlich-Kister, UNIQUAC, NRTL and Wilson models in the solubility data representation were investigated. Two versions of Yalkowsky model were employed to estimate the solubility data. Dissolution and mixing apparent thermodynamic functions for mesalazine in studied solvents were also evaluated. Moreover, by means of inverse Kirkwood-Buff integrals method it is demonstrated that this drug is preferentially solvated by water in all the mixtures. © 2018 Elsevier B.V.
Related Docs
View other Related Docs
1. Solubility of Mesalazine in {Acetonitrile + Water} Mixtures at Various Temperatures, Physics and Chemistry of Liquids (2021)
2. Solubility of Mesalazine in {1-Propanol/Water} Mixtures at Different Temperatures, Journal of Molecular Liquids (2020)
3. Measurement and Modelling of the Solubility for Ketoconazole in {Acetonitrile + Water} Mixtures at T = (293.2 to 313.2) K, Physics and Chemistry of Liquids (2021)
Experts (# of related papers)
Alireza Foroumadi (1)
Other Related Docs
4. The Solubility of Ketoconazole in Binary Carbitol + Water Mixtures at T = (293.2–313.2) K, Journal of Molecular Liquids (2020)
5. Solubility of 5-Aminosalicylic Acid in {N-Methyl-2-Pyrrolidone + Ethanol} Mixtures at T = (293.2 to 313.2) K, Journal of Molecular Liquids (2020)
6. Solubility of Ketoconazole in 1,4-Dioxane + Water Mixtures at T = (293.2 to 313.2) K, Journal of Molecular Liquids (2020)
7. Solubility of 5-Aminosalicylic Acid in N-Methyl-2-Pyrrolidone + Water Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)
8. Mesalazine Solubility in the Binary Mixtures of Ethanol and Water at Various Temperatures, Physics and Chemistry of Liquids (2021)
9. Mesalazine Solubility in Propylene Glycol and Water Mixtures at Various Temperatures Using a Laser Monitoring Technique, Journal of Molecular Liquids (2020)
10. Further Comments on “Experimental Measurements, Equilibrium Study and Model Correlation of Methyl Paraben in Ethanol and Methanol Aqueous Solutions From = (293.15 to 323.15) K”, Journal of Molecular Liquids (2020)
11. A Laser Monitoring Technique for Determination of Mesalazine Solubility in Propylene Glycol and Ethanol Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)
12. Simulation of Mesalazine Solubility in the Binary Solvents at Various Temperatures, Journal of Molecular Liquids (2022)
13. Predicting the Solubility, Thermodynamic Properties and Preferential Solvation of Sulphamethazine in {Acetonitrile + Water} Mixtures Using a Minimum Number of Experimental Data Points, Physics and Chemistry of Liquids (2021)
14. Solubility of Meloxicam in (Carbitol® + Water) Mixtures: Determination, Correlation, Dissolution Thermodynamics and Preferential Solvation, Journal of Molecular Liquids (2021)
15. Dissolution Thermodynamics and Preferential Solvation of Ketoconazole in Some {Ethanol (1) + Water (2)} Mixtures, Journal of Molecular Liquids (2020)
16. Solubility of Mesalazine in Polyethylene Glycol 400 + Water Mixtures at Different Temperatures, Journal of Molecular Liquids (2020)
17. Preferential Solvation of 4-(4-Ethoxyphenyl)-5-(3,4,5-Trimethoxybenzoyl)-3,4-Dihydropyrimidin-2(1H)-One in {Peg 400 (1) + Water (2)} Mixtures, Physics and Chemistry of Liquids (2021)
18. Further Numerical Analyses on the Solubility of Diazepam in Aqueous Tert-Butanol Mixtures, Physics and Chemistry of Liquids (2021)
19. Solubility of Codeine Phosphate in Carbitol + 2-Propanol Mixture at Different Temperatures, Drug Development and Industrial Pharmacy (2020)
20. Solubilization of Naproxen: Experimental Data and Computational Tools, Journal of Molecular Liquids (2019)
21. Computational Tools for Solubility Prediction of Celecoxib in the Binary Solvent Systems, Journal of Molecular Liquids (2020)
22. Preferential Solvation of Some Corticosteroids in {Ethanol (1) + Water (2)} Mixtures at 298.2 K, Journal of Molecular Liquids (2020)
23. Solubility of Caffeine in Carbitol + Ethanol Mixture at Different Temperatures, Journal of Molecular Liquids (2020)
24. Solubilization of Bosentan Using Ethanol As a Pharmaceutical Cosolvent, Journal of Molecular Liquids (2017)
25. Solubility of Codeine Phosphate in N-Methyl-2-Pyrrolidone +2-Propanol Mixture at Different Temperatures, Journal of Molecular Liquids (2020)
26. Comments Concerning “Solvent Effect and Preferential Solvation of Cefpiramide in Cosolvent Plus Water Mixtures”, Journal of Molecular Liquids (2019)
27. Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling, Physics and Chemistry of Liquids (2021)
28. Trained Models for Solubility Prediction of Drugs in Acetonitrile + Water Mixtures at Various Temperatures, Physics and Chemistry of Liquids (2021)
29. Solubility of Sildenafil Citrate in the Binary Mixtures of Ethylene Glycol and Water at Different Temperatures, Journal of Molecular Liquids (2020)