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Mesalazine Solubility in the Binary Mixtures of Ethanol and Water at Various Temperatures Publisher



Alvanialamdari S1 ; Rezaei H2 ; Rahimpour E3, 4 ; Hemmati S1 ; Martinez F5 ; Barzegarjalali M6 ; Jouyban A3, 7
Authors
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Authors Affiliations
  1. 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia–Sede Bogota, Bogota, D.C., Colombia
  6. 6. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Physics and Chemistry of Liquids Published:2021


Abstract

This study reports the experimental mesalazine solubility data in the binary mixtures of ethanol and water at temperature ranges of 293.2–313.2 K. The generated data are correlated with six co-solvency mathematical models including the van’t Hoff, the mixture response surface, the Yalkowsky, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, and the modified Wilson models, and the mean relative deviations (MRD%) of the back-calculated solubility for each investigated model are reported. Density of the mesalazine saturated solutions as another physicochemical property are also fitted by the Jouyban–Acree model. Moreover, standard enthalpy, entropy and Gibbs free energy changes for mesalazine dissolution process are obtained by using the van’t Hoff and Gibbs equations. Furthermore, by means of inverse Kirkwood-Buff integrals is observed that mesalazine is preferentially solvated by water in almost all the mixtures studied. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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