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Solubility of 5-Aminosalicylic Acid in N-Methyl-2-Pyrrolidone + Water Mixtures at Various Temperatures Publisher



Jouyban K1, 2 ; Mazaher Haji Agha E1, 3 ; Hemmati S4 ; Martinez F5 ; Kuentz M6 ; Jouyban A1, 7
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Research and Development Department, Daana Pharmaceutical Company, Tabriz, Iran
  4. 4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia – Sede Bogota, Cra. 30 No. 45-03, Bogota, D.C., Colombia
  6. 6. Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstr. 30, Muttenz, 4132, Switzerland
  7. 7. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

Drug solubility studies in solvent mixtures have great importance in the pharmaceutical sciences especially in pharmaceutical technology. Advancements in thermodynamic modeling enable a better mechanistic understanding and can provide guidance in the development of promising solvent mixtures for a given drug. This work studied equilibrium solubility of 5-aminosalicylic acid (mesalazine) in mixed solvents using N-methyl-2-pyrrolidone (NMP) and water at T = (293.2 to 313.2) K. The obtained solubility data were described mathematically by the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC and NRTL models. To discuss the solute-solvent interactions, the activity coefficients of mesalazine were determined in the investigated mixtures. Calculation of the apparent thermodynamic properties of dissolution and mixing for mesalazine, as well as, the preferential solvation parameters in the studied mixtures provided valuable molecular insights into the studied model system and the results are of practical relevance in case of mesalazine. © 2018 Elsevier B.V.
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