Marketed Antiparasitic Nanotechnology-Based Products and Drawbacks Publisher



Khayatan D^{1, 2} ; Momtaz S^{3, 4} ; Abdolghaffari AH^{1, 2} ; Ashari S⁵ ; Jangjoo A⁶ ; Sahebkar A^{5, 7, 8} Show Affiliations
Source: Advances in Antiparasitic Therapies and Drug Delivery Published:2023

Abstract

Parasites cause many diseases throughout the world. Parasitic diseases are often affected by the host's immune status, which determines the severity and outcome of the disease. Humans have become more susceptible to infection by each type of parasite as our lifestyles have changed. Depending on geographical location and ethnic background, there can be significant differences in the prevalence of different pathogens. Infections can be transmitted by third parties, such as domestic animals or flies. Parasite infections can be effectively treated with several effective drugs. Most conventional drug-delivery systems have an immediate high drug release after administration, thus leading to increased administration frequency. Thus, many studies have been carried out worldwide focusing on the development of pharmaceutical nanomedicines for translation into products manufactured by local pharmaceutical companies. Currently, nanoscale materials and scaffolds carrying antiparasitic agents to the target site are practical approaches for infectious treatment. Pharmaceutical nanomedicine products are projected to play a major role in the global pharmaceutical market and healthcare system. Our objectives were to examine the nanomedicines approved by the Food and Drug Administration and the European Medicines Agency in the global market to briefly cover the challenges faced during their development and to look at future perspectives. Additionally, the importance of nanotechnology in developing pharmaceutical products, the ideal properties of nanocarriers, the reasons behind the failure of some nanomedicines, and the important considerations in the development of nanomedicines will be discussed in brief. © 2024 Elsevier Inc. All rights reserved.