Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Inherited and Acquired Immunodeficiencies Underlying Tuberculosis in Childhood Publisher Pubmed



Boissondupuis S1, 2, 3 ; Bustamante J1, 2, 3, 4 ; Elbaghdadi J5 ; Camcioglu Y6 ; Parvaneh N7, 8 ; El Azbaoui S5, 9 ; Agader A10 ; Hassani A10 ; El Hafidi N11, 12 ; Mrani NA13 ; Jouhadi Z10 ; Ailal F14 ; Najib J14 ; Reisli I15 Show All Authors
Authors
  1. Boissondupuis S1, 2, 3
  2. Bustamante J1, 2, 3, 4
  3. Elbaghdadi J5
  4. Camcioglu Y6
  5. Parvaneh N7, 8
  6. El Azbaoui S5, 9
  7. Agader A10
  8. Hassani A10
  9. El Hafidi N11, 12
  10. Mrani NA13
  11. Jouhadi Z10
  12. Ailal F14
  13. Najib J14
  14. Reisli I15
  15. Zamani A16
  16. Yosunkaya S16
  17. Gullegirit S17
  18. Yildiran A18
  19. Cipe FE19
  20. Torun SH20
  21. Metin A21
  22. Atikan BY22
  23. Hatipoglu N23
  24. Aydogmus C24
  25. Kilic SS25
  26. Dogu F19
  27. Karaca N26
  28. Aksu G26
  29. Kutukculer N26
  30. Keseremiroglu M27
  31. Somer A28
  32. Tanir G29
  33. Aytekin C30
  34. Adimi P31
  35. Mahdaviani SA31
  36. Mamishi S32
  37. Bousfiha A33
  38. Sanal O34
  39. Mansouri D35
  40. Casanova JL1, 2, 3, 36, 37
  41. Abel L1, 2, 3

Source: Immunological Reviews Published:2015


Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb) and a few related mycobacteria, is a devastating disease, killing more than a million individuals per year worldwide. However, its pathogenesis remains largely elusive, as only a small proportion of infected individuals develop clinical disease either during primary infection or during reactivation from latency or secondary infection. Subacute, hematogenous, and extrapulmonary disease tends to be more frequent in infants, children, and teenagers than in adults. Life-threatening primary TB of childhood can result from known acquired or inherited immunodeficiencies, although the vast majority of cases remain unexplained. We review here the conditions conferring a predisposition to childhood clinical diseases caused by mycobacteria, including not only M.tb but also weakly virulent mycobacteria, such as BCG vaccines and environmental mycobacteria. Infections with weakly virulent mycobacteria are much rarer than TB, but the inherited and acquired immunodeficiencies underlying these infections are much better known. Their study has also provided genetic and immunological insights into childhood TB, as illustrated by the discovery of single-gene inborn errors of IFN-γ immunity underlying severe cases of TB. Novel findings are expected from ongoing and future human genetic studies of childhood TB in countries that combine a high proportion of consanguineous marriages, a high incidence of TB, and an excellent clinical care, such as Iran, Morocco, and Turkey. © 2015 John Wiley & Sons A/S.
Other Related Docs
4. Common Presentations and Diagnostic Approaches, Stiehm's Immune Deficiencies: Inborn Errors of Immunity (2020)
7. Defects in Innate Immunity: Receptors and Signaling Components, Encyclopedia of Infection and Immunity (2022)
11. Primary Immunodeficiencies and Cancers, Cancer Immunology: A Translational Medicine Context (2015)
13. Inborn Errors of Immunity and Cancers, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)