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Gmp-Compliant Production of Human Placenta-Derived Mesenchymal Stem Cells Publisher Pubmed



Aghayan HR1 ; Payab M2 ; Mohamadijahani F3 ; Aghayan SS4 ; Larijani B5 ; Arjmand B1, 6
Authors

Source: Methods in Molecular Biology Published:2021


Abstract

Mesenchymal stem cells are one of the most attractive sources for stem cell research and therapy. Their safety and efficacy have been demonstrated in many clinical trials. Because of their low immunogenicity and immunomodulatory properties, allogenic MSCs have been transplanted in different clinical studies. MSCs could be in different adult- and fetal-derived tissues including pregnancy products. Placenta-derived mesenchymal stem cells (PLMSCs) that can be harvested without using any invasive procedures from a discarding tissue are one of the important types of mesenchymal stem cells for therapeutic applications. Stem cell manufacturing for therapeutic applications should be in compliance with the basic principles of good manufacturing practice (GMP). Herein, the current chapter is to describe GMP-compliant production of human PLMSCs, which are suitable for clinical applications. © 2020, Springer Science+Business Media New York.
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Babak Arjmand (8)
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