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The Therapeutic Effects of Olive Leaf Extract on Leishmania Major Infection in Balb/C Mice Publisher



Kheirandish F1 ; Mahmoudvand H1 ; Khamesipour A2 ; Ebrahimzadeh F3 ; Behrahi F4 ; Rezaei S4 ; Delfan B5
Authors
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Authors Affiliations
  1. 1. Department of Parasitology and Mycology, School of Medicine, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biostatistics, School of Health and Nutrition, Lorestan University of Medical Sciences, P.O. Box 381351698, Khorramabad, Iran
  4. 4. School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  5. 5. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Source: Marmara Pharmaceutical Journal Published:2017


Abstract

At present, no effective vaccine has been found for CL; thus, the upgrading and improvement of the present drugs and development of the novel agents have been demonstrated to be the merely control choice for this disease. The present study aims to evaluate the effects of olive leaf extract (Olea europaea L. OLE) on Leishmania major infection in BALB/c mice. OLE tested on cutaneous leishmaniasis (CL) in male BALB/c mice with L. major promastigotes (MRHO/IR/75/ER) at the doses of 10, 20, and 30 mg/kg. Results demonstrated that after treatment of the groups with the concentrations of 10, 20, and 40 mg/ kg of OLE, mean diameter of lesions was reduced by 2.16, 5.87, and 7.61 cm, respectively. Moreover, after 4 weeks of treatment, 83.3%, 66.64%, and 33.32% recovery was observed in the infected mice treated with 40, 20, and 10 mg/kg of OLE, respectively. In conclusion, the present study showed OLE has potent therapeutic effects on cutaneous leishmaniasis. © 2017, Marmara University. All rights reserved.
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