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Down-Regulation of a Panel of Immune-Related Lncrnas in Breast Cancer Publisher Pubmed



Ghafourifard S1 ; Asadi M2 ; Sohrabi B3 ; Arsangjang S4 ; Mehravaran E5 ; Taheri M6 ; Samsami M7
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biology, Islamic Azad University, Urmia Branch, Urmia, Iran
  3. 3. Department of Biology, Faculty of Sciences, Arak University, Arak, Iran
  4. 4. Cancer Gene therapy Research Center, Zanjan University of Medical Science, Zanjan, Iran
  5. 5. Motamed Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Surgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2021


Abstract

Breast cancer is a common neoplasm among women. This type of cancer is among malignancies in which role of long non-coding RNAs (lncRNAs) has been extensively explored. Some recently recognized lncRNAs have been less investigated in this neoplastic condition. LncRNAs that regulate tumor immunity are among those contributing in the pathogenesis of cancer. In the present expression assay, we compared expressions of nine immune-related lncRNAs namely lnc-MICAL3–2 (AC016027.1), lnc-DDX31 (AL445645.1), LINC01063, LINC02381, ENST0000615051 (AC083809.1), AC009237.14 (lnc-TRIM43B-1), ENST0000603791, LINC1234 and AC008760.1 between breast cancer samples and their paired non-cancerous samples. Expression levels of lnc-MICAL3–2, lnc-DDX31, LINC01063, LINC02381, ENST0000615051 and lnc-TRIM43B-1 were significantly decreased in breast cancer samples compared with paired control tissues (Posterior mean difference= −2.774, −2.012, −2.012, −2.015, −0.884 and −2.872; P values= 0.019, 0.0001, 0.0001, 0.0001, 0.032 and 0.0001, respectively). Expression levels of these lncRNAs have been associated with a number of clinical characteristics of breast cancer patients. Lnc-TRIM43B-1 had the highest performance in distinguishing between tumoral and non-tumoral tissues (AUC=0.82, Sensitivity=76%, Specificity=73.24%). As these lncRNAs could differentiate tumor samples from control samples, they might be regarded as putative tissue markers for breast cancer. © 2021 Elsevier GmbH
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