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Effects of Body Weight Regain on Leptin Levels: A Systematic Review and Meta-Analysis Publisher Pubmed



Rostami Rayeni N1 ; Abdollahzad H2 ; Alibakhshi P3 ; Morvaridzadeh M4 ; Heydari H5 ; Dehnad A6 ; Khorshidi M1, 7 ; Izadi A8, 9 ; Shidfar F1 ; Dulce Estevao M10 ; Omidi A4 ; Heshmati J4
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  6. 6. Department of English Language, School of Health Management and Information Sciences, Center for Educational Research in Medical Sciences (CERMS), Iran University of Medical Sciences, Iran
  7. 7. Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Iran Football Medical Assessment and Rehabilitation Center (IFMARC), Tehran, Iran
  9. 9. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Universidade do Algarve, Escola Superior de Saude, Campus de Gambelas, Faro, Portugal

Source: Cytokine Published:2021


Abstract

Background: There are different changes observed before and after diet therapy, and also after weight regain. However, there is not sufficient information regarding weight regain and hormonal changes. Purpose: The purpose of this study was to review the connection between weight regain and leptin concentration levels. Methods: MEDLINE, SCOPUS, Web of Science, and the Cochrane Library were searched for interventional articles published from January 1, 1980, to June 30, 2020. Randomized clinical trials with parallel or cross over design assessing leptin concentrations at the baseline and at the end of study were reviewed. Two independent reviewers extracted data related to study design, year of publication, country, age, gender, body mass index (BMI), duration of the following up period and mean ± SD of other intended variables. Results: Four articles were included, published between 2004 and 2016. Three of them were conducted in the US and one of them in Netherland. Sample size of the studies ranged between 25 and 148 participants. The range of following up period was from13 to 48 weeks. The age range of participants was from 34 to 44 years. Our analysis shows that weight regain could reduce leptin levels, but this change is not statistically significant. Conclusion: This review suggests that weight regain may induce a non-significant reduction in leptin level. However, the limited number and great heterogeneity between the included studies may affect the presented results and there are still need to well-designed, large population studies to determine the relationship between weight regain and leptin levels. © 2021 Elsevier Ltd
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