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The Effect of Zinc Supplementation on Serum Leptin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Khorshidi M1 ; Zarezadeh M2 ; Sadeghi A2 ; Teymouri A3 ; Emami MR4 ; Kordvarkaneh H5 ; Aryaeian N6 ; Rahmani J7 ; Mousavi SM8, 9
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Authors Affiliations
  1. 1. Stud. Research Committee, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cellular and Molecular Nutrition, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Nutrition, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Stud. Research Committee, Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Nutrition Department, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Community Nutrition, Shahid Behehshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), No. 44, Hojjat-dost Alley, Naderi Sta, Keshavarz Blvd., Tehran, Iran
  9. 9. Stud. Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Hormone and Metabolic Research Published:2019


Abstract

Recently, obesity has become a common worldwide concern. Leptin, as an adipocytokine, plays a major role in the etiology of obesity. Prior studies have demonstrated that zinc potentially affects serum leptin levels. However, clinical trials carried out in this regard are not consistent. Therefore, current meta-analysis was conducted to ascertain the actual effect of zinc supplementation on serum leptin levels in adults. Databases of PubMed, SCOPUS, and Google Scholar were methodically searched to identify relevant articles up to April 2018. Clinical trials that examined the effect of zinc supplementation on serum leptin concentrations as outcome variables in human adults were included. The mean difference (SD) of leptin changes in the intervention and placebo groups were used to calculate the overall effect size. Totally, 663 articles were identified, of which 6 studies were eligible randomized controlled trials (RCTs) with 7 treatment arms. The analysis suggested that zinc supplementation exerts no significant effect on overall serum leptin (WMD: 0.74 ng/ml; 95% CI: -1.39 to 2.87, p=0.49). Nevertheless, sex and duration of intervention seemed to impact the extent of zinc's influence. In trials with female subjects, zinc consumption led to a significant decrease in serum leptin level (WMD: -1.93 ng/ml; 95% CI: -3.72 to -0.14, p=0.03) as well as trials that lasted for more than 6 weeks (WMD: -1.71 ng/ml; 95% CI: -3.07 to -0.35, p=0.01), in comparison to the control group. Zinc supplementation did not significantly improve leptin concentrations, but it may result in a decreased circulating leptin level in studies with a duration of more than 6 weeks especially among females. © 2019 Georg Thieme Verlag KG Stuttgart · New York.
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