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Keshavarzfathi M1, 2, 3 ; Rezaei N3, 4, 5
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2019


Abstract

The efficacy of cancer vaccines as a monotherapy may be undervalued because of immunosuppression and immune regulatory functions. Combining vaccines with other therapeutics can overcome these barriers and enhance the efficacy of cancer vaccines. Cancer vaccines have been combined with other therapeutics such as chemotherapy, radiation therapy, and small molecule inhibitors, as well as immunotherapy such as cytokines, immune checkpoint inhibitors, and tumor targeted monoclonal antibodies. These combinations have been evaluated in many preclinical and clinical studies. Here, we will review these combination therapies and their potential for improving the efficacy of vaccines. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd. All rights reserved.
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