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Host Factors: Implications in Immunopathogenesis of Covid-19 Publisher Pubmed



Jafarpour R1 ; Pashangzadeh S2, 3 ; Dowran R4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Immunology Today, Universal Scientific Education and Research Network (USERN), Tehan, Iran
  4. 4. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2021


Abstract

Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is more serious in people with underlying diseases, but the cause of healthy people with progressive disease is largely unknown. Host genetic factors such as ACE2 variants, IFITM-3, HLA, TMRSS2, and furin polymorphisms appear to be one of the agents involved in the progression of the COVID-19 and outcome of the disease. This review discusses the general characteristics of SARS-CoV-2, including viral features, receptors, cell entry, clinical findings, and the main human genetic factors that may contribute to the pathogenesis of COVID-19 and get the patients’ situation more complex. Further knowledge in this context may help to find a way to prevent and treat this viral pneumonia. © 2021 Elsevier GmbH
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