Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics Publisher Pubmed



Saie AA1, 2 ; Ray M5 ; Mahmoudi M2, 3, 4 ; Rotello VM5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
  2. 2. Nanotechnology Research Center, Department of Nanotechnology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Division of Cardiovascular Medicine, Department of Medicine, Stanford University, School of Medicine, Stanford, CA, United States
  4. 4. Division of Cardiology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States
  5. 5. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, 01003, MA, United States

Source: Cancer Treatment and Research Published:2015


Abstract

Intracellular delivery of functional proteins using nanoparticles can be a game-changing approach for cancer therapy. However, cytosolic release of functional protein is still a major challenge. In addition, formation of protein corona on the surface of the nanoparticles can also alter the behavior of the nanoparticles. Here, we will review recent strategies for protein delivery into the cell. Finally we will discuss the issue of protein corona formation in light of nanoparticle-protein interactions. © Springer International Publishing Switzerland 2015.
Related Docs
View other Related Docs
1. Targeted Superparamagnetic Iron Oxide Nanoparticles for Early Detection of Cancer: Possibilities and Challenges, Nanomedicine: Nanotechnology# Biology# and Medicine (2016)
2. Protein Corona Variation in Nanoparticles Revisited: A Dynamic Grouping Strategy, Colloids and Surfaces B: Biointerfaces (2019)
3. Gold Nanoparticles for Biomedical Imaging and Their Biological Response, New Developments in Gold Nanomaterials Research (2016)
4. Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona, ACS Nano (2016)
5. The Importance of Selecting a Proper Biological Milieu for Protein Corona Analysis in Vitro: Human Plasma Versus Human Serum, International Journal of Biochemistry and Cell Biology (2016)
6. Disease Specific Protein Corona, Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2015)
7. Multiscale Technologies for Treatment of Ischemic Cardiomyopathy, Nature Nanotechnology (2017)
8. Nanoparticles and Biological Environment Interactions, Advanced Structured Materials (2019)
Experts (# of related papers)
View all Related Experts
Mohamad Raoufi (12)
Fatemeh Atyabi (10)
Other Related Docs
9. Impact of Protein Pre-Coating on the Protein Corona Composition and Nanoparticle Cellular Uptake, Biomaterials (2016)
10. Nanotoxicology: Advances and Pitfalls in Research Methodology, Nanomedicine (2015)
11. Protein Corona: Opportunities and Challenges, International Journal of Biochemistry and Cell Biology (2016)
12. Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities, Chemical Reviews (2019)
13. Biological Identity of Nanoparticles in Vivo: Clinical Implications of the Protein Corona, Trends in Biotechnology (2017)
14. Synthetic and Biological Identities of Polymeric Nanoparticles Influencing the Cellular Delivery: An Immunological Link, Journal of Colloid and Interface Science (2019)
15. Photothermal Effects on Protein Adsorption Dynamics of Pegylated Gold Nanorods, Applied Materials Today (2019)
16. Superparamagnetic Iron Oxide Nanoparticles for in Vivo Molecular and Cellular Imaging, Contrast Media and Molecular Imaging (2015)
17. Protein Corona: Challenges and Opportunities for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments# Tools and Devices (2024)
18. Pegylated Magnetic Mesoporous Silica Nanoparticles Decorated With As1411 Aptamer As a Targeting Delivery System for Cytotoxic Agents, Pharmaceutical Development and Technology (2019)
19. Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties, ACS Nano (2016)
20. Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles, Nanomedicine (2015)
21. Bypassing Protein Corona Issue on Active Targeting: Zwitterionic Coatings Dictate Specific Interactions of Targeting Moieties and Cell Receptors, ACS Applied Materials and Interfaces (2016)
22. Molecular Interaction of Fibrinogen With Zeolite Nanoparticles, Scientific Reports (2019)
23. Biomedical Applications of Superparamagnetic Nanoparticles in Molecular Scale, Current Organic Chemistry (2015)
24. Novel Therapeutic Strategies for Alzheimer's Disease: Implications From Cell-Based Therapy and Nanotherapy, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
25. Biomolecular Corona Dictates Aβ Fibrillation Process, ACS Chemical Neuroscience (2018)
26. Sensing of Alzheimer's Disease and Multiple Sclerosis Using Nano-Bio Interfaces, Journal of Alzheimer's Disease (2017)
27. Monoclonal Antibody Conjugated Magnetic Nanoparticles Could Target Muc-1-Positive Cells in Vitro But Not in Vivo, Contrast Media and Molecular Imaging (2015)
28. Dual Nano-Sized Contrast Agents in Pet/Mri: A Systematic Review, Contrast Media and Molecular Imaging (2016)
29. Misinterpretation in Nanotoxicology: A Personal Perspective, Chemical Research in Toxicology (2016)
30. The Bio-Interface Between Functionalized Au Nr@Go Nanoplatforms With Protein Corona and Their Impact on Delivery and Release System, Colloids and Surfaces B: Biointerfaces (2019)
31. Theranostic Muc-1 Aptamer Targeted Gold Coated Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging and Photothermal Therapy of Colon Cancer, Colloids and Surfaces B: Biointerfaces (2016)
32. The Impact of Protein Corona on the Biological Behavior of Targeting Nanomedicines, International Journal of Pharmaceutics (2022)
33. Does Pharmacodynamics of Drugs Change After Presenting Them As Na-Noparticles Like Their Pharmacokinetics?, Current Drug Targets (2020)
34. Unveiling the Theranostic Potential of Spions in Alzheimer's Disease Management, Journal of Psychiatric Research (2024)
35. Zeolite Nanoparticles Inhibit Aβ-Fibrinogen Interaction and Formation of a Consequent Abnormal Structural Clot, ACS Applied Materials and Interfaces (2016)
36. Transferrin Receptor-Mediated Liposomal Drug Delivery: Recent Trends in Targeted Therapy of Cancer, Expert Opinion on Drug Delivery (2022)
37. Development of 177Lu-Dtpa-Spio Conjugates for Potential Use As a Dual Contrast Spect/Mri Imaging Agent, Radiochimica Acta (2016)
38. Toxicity of Inorganic Nanoparticles, Comprehensive Analytical Chemistry (2022)
39. Bare Surface of Gold Nanoparticle Induces Inflammation Through Unfolding of Plasma Fibrinogen, Scientific Reports (2018)
40. Protein Corona Hampers Targeting Potential of Muc1 Aptamer Functionalized Sn-38 Core-Shell Nanoparticles, International Journal of Pharmaceutics (2015)
41. Solid Silica Nanoparticles: Applications in Molecular Imaging, Contrast Media and Molecular Imaging (2015)
42. The Effect of Fibronectin Coating on Protein Corona Structure and Cellular Uptake of Single-Walled Carbon Nanotubes, Precision Nanomedicine (2020)
43. Advances in Alzheimer's Diagnosis and Therapy: The Implications of Nanotechnology, Trends in Biotechnology (2017)
44. Controlled Anti-Cancer Drug Release Through Advanced Nano-Drug Delivery Systems: Static and Dynamic Targeting Strategies, Journal of Controlled Release (2020)
45. Impact of Plasma Concentration of Transferrin on Targeting Capacity of Nanoparticles, Nanoscale (2020)
46. Magneto-Fluorescent Contrast Agents Based on Carbon Dots@Ferrite Nanoparticles for Tumor Imaging, Journal of Magnetism and Magnetic Materials (2022)
47. Characterization of Protein Corona Formation on Nanoparticles Via the Analysis of Dynamic Interfacial Properties: Bovine Serum Albumin - Silica Particle Interaction, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
48. Current Developments in Antimicrobial Surface Coatings for Biomedical Applications, Current Medicinal Chemistry (2015)
49. A Novel Strategy for Enhance Potentiation of Meglumine Antimoniate Against Leishmania Major in Vitro, Iranian Journal of Parasitology (2019)
50. Optimization of Docetaxel Loading Conditions in Liposomes: Proposing Potential Products for Metastatic Breast Carcinoma Chemotherapy, Scientific Reports (2020)