Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection

Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection Publisher Pubmed

Shirazi H^{1, 2} ; Ahmadi A² ; Darzianiazizi M² ; Kashanian S² ; Kashanian S² ; Omidfar K^{1, 2, 4}

Show Affiliations

1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, IR, Iran
2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, IR, Iran
3. Department of Chemistry, Sensor and Biosensor Research Center (SBRC), Nanoscience and Nanotechnology Research Center (NNRC), Faculty of Science, Razi University, Kermanshah, IR, Iran
4. Biosensor Research Center, Endocrinology and Metabolism Cellular and Molecular Sciences Institute, Tehran University of Medical Sciences, P.O. Box 14395, Tehran, 1179, Iran

Source: IET Nanobiotechnology Published:2016

Abstract

This study presents a novel signal amplification method for high-sensitive electrochemical immunosensing. Gold (Au)/N-trimethyl chitosan (TMC)/iron oxide (Fe3O4) (shell/shell/core) nanocomposite was used as a tracing tag to label antibody. The tag was shown to be capable of amplifying the recognition signal by high-density assembly of Au nanoparticles (NPs) on TMC/Fe3O4 particles. The remarkable conductivity of AuNPs provides a feasible pathway for electron transfer. The method was found to be simple, reliable and capable of high-sensitive detection of human serum albumin as a model, down to 0.2 pg/ml in the range of 0.25-1000 pg/ml. Findings of the present study would create new opportunities for sensitive and rapid detection of various analytes. © The Institution of Engineering and Technology 2016.

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Kobra Omidfar (10)

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Style	Citing Format
MLA	Shirazi H, et al.. "Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection." IET Nanobiotechnology, vol. 10, no. 1, 2016, pp. 20-27.
APA	Shirazi H, Ahmadi A, Darzianiazizi M, Kashanian S, Kashanian S, Omidfar K (2016). Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection. IET Nanobiotechnology, 10(1), 20-27.
Chicago	Shirazi H, Ahmadi A, Darzianiazizi M, Kashanian S, Kashanian S, Omidfar K. "Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection." IET Nanobiotechnology 10, no. 1 (2016): 20-27.
Harvard	Shirazi H et al. (2016) 'Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection', IET Nanobiotechnology, 10(1), pp. 20-27.
Vancouver	Shirazi H, Ahmadi A, Darzianiazizi M, Kashanian S, Kashanian S, Omidfar K. Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection. IET Nanobiotechnology. 2016;10(1):20-27.
BibTex	@article{ author = {Shirazi H and Ahmadi A and Darzianiazizi M and Kashanian S and Kashanian S and Omidfar K}, title = {Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection}, journal = {IET Nanobiotechnology}, volume = {10}, number = {1}, pages = {20-27}, year = {2016} }
RIS	TY - JOUR AU - Shirazi H AU - Ahmadi A AU - Darzianiazizi M AU - Kashanian S AU - Kashanian S AU - Omidfar K TI - Signal Amplification Strategy Using Gold/N-Trimethyl Chitosan/Iron Oxide Magnetic Composite Nanoparticles As a Tracer Tag for High-Sensitive Electrochemical Detection JO - IET Nanobiotechnology VL - 10 IS - 1 SP - 20 EP - 27 PY - 2016 ER -

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