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Exploring the Potential of Bioactive Compounds in Preventing Cancer Growth and Progression: A Comprehensive Review Publisher



Foroughigilvaee MR1 ; Martirosyan D2 ; Mashayekhnia MJ3 ; Maadi MA4 ; Sarvendani MRR5 ; Maghsoumi M6
Authors
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Authors Affiliations
  1. 1. Department of Health Education and Promotion, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Functional Food Center, Functional Food Institute, Dallas, TX, United States
  3. 3. Resident of Veterinary Clinical Pathology, Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran
  4. 4. Resident of veterinary surgery and orthopedics, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
  5. 5. Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  6. 6. Department of Clinical Science, Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Tehran, Iran

Source: Bioactive Compounds in Health and Disease Published:2024


Abstract

Cancer stands as a prominent global cause of mortality, with a noteworthy surge in related deaths in recent years. Over the past decade, several bioactive compounds have emerged as potent agents in impeding the relentless advance of cancer. Notably, numerous studies highlight the efficacy of natural plant-derived bioactive compounds in augmenting chemotherapy outcomes and mitigating adverse drug effects associated with chemotherapeutic agents. This comprehensive review investigates the anticancer effects of three types of bioactive compounds: polyphenols, alkaloids, and terpenoids. It elucidates their mechanisms of action and consolidates evidence from preclinical studies. Furthermore, this review delves into the molecular mechanisms through which these active compounds may manifest their anticancer properties, drawing insights from cell and animal-based studies. ©FFC 2024.
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