Tehran University of Medical Sciences

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Sirna-Based Nucleoceuticals for Tissue Regeneration Publisher



Atyabi F1 ; Mottaghitalab F1 ; Rastegari A1
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  1. 1. Tehran University of Medical Sciences, Tehran, Iran

Source: Nanostructures for Novel Therapy: Synthesis# Characterization and Applications Published:2017


Abstract

The field of tissue engineering and regenerative medicine has exploded the use of small interfering RNA (siRNA) to turn off proteins that prevent the application of regenerative therapies. siRNA is a potent biomolecule for regulating the cellular behavior in tissue engineering applications, and spatially patterning its presentation to cells may ultimately facilitate the engineering of complex tissues. siRNA has a wide therapeutic application for treating diseases or augmenting tissue formation. The use of siRNA to reduce the expression of a target gene can induce the expression of one or more tissue-inductive factors, direct the differentiation of stem or progenitor cells, or remove a factor that inhibits regeneration. This issue can be useful in fundamental studies of tissue formation to promote in vivo regeneration. siRNA has a potential to be used as a nucleoceutical component for regenerating different tissues including bone, cartilage, skin, heart, kidney, liver, and nerve regeneration. This chapter will provide an in-depth discussion of the development of siRNA-based nucleoceuticals for tissue engineering applications. © 2017 Elsevier Inc. All rights reserved.
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