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Silk As a Potential Candidate for Bone Tissue Engineering Publisher Pubmed



Mottaghitalab F1 ; Hosseinkhani H2 ; Shokrgozar MA3 ; Mao C4 ; Yang M5 ; Farokhi M3
Authors
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Authors Affiliations
  1. 1. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, 10607, Taipei, Taiwan
  3. 3. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, 73019, OK, United States
  5. 5. Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, 310058, Zhejiang, China

Source: Journal of Controlled Release Published:2015


Abstract

Abstract Regeneration of large bone defects is challenging in the next few years because the age of the population is growing. Bone grafting as a gold standard of bone repairing is limited as a result of many disadvantages. In recent years, many novel materials and processing methods have been introduced to construct the native bone extracellular matrix (ECM) and restore the functions of degenerated bone. Silk fibroin (SF) as a natural polymer, has established a good reputation for bone tissue engineering applications due to its many unique properties, including exceptional biocompatibility, biodegradability, mechanical behavior, and ease of processability. In this review, recent advances in the design and application of SF-based scaffolds for bone regeneration are discussed. © 2015 Elsevier B.V.
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