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The Therapeutic Effect of Exosomes From Mesenchymal Stem Cells on Colorectal Cancer: Toward Cell-Free Therapy Publisher Pubmed



Karami Fath M1 ; Anjomrooz M2 ; Taha SR3 ; Shariat Zadeh M4 ; Sahraei M5 ; Atbaei R6 ; Fazlollahpour Naghibi A4 ; Payandeh Z7 ; Rahmani Z8 ; Barati G9
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  2. 2. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Medicine, Islamic Azad University, Tehran Branch, Tehran, Iran
  4. 4. Faculty of Medicine, Islamic Azad University, Sari Branch, Sari, Iran
  5. 5. Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
  7. 7. Department of Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, Sweden
  8. 8. Faculty of Paramedical, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  9. 9. Stem Cell Technology Research Center, Tehran, Iran

Source: Pathology Research and Practice Published:2022


Abstract

Colorectal cancer (CRC) is known for its high mortality rate and affects more men than women. The treatment requires invasive surgical interventions, however, the progression of CRC metastasis is difficult to control in most cases. Mesenchymal stem cells (MSCs) with their outstanding characteristics have been widely used in the treatment of degenerative diseases as well as cancers. They affect the tumor microenvironment through either cell-cell interactions or communications with their secretome. While stem cells may represent a dual role in tumor proliferation and progression, exosomes have attracted much attention as a cell-free therapy in CRC treatment. Exosomes derived from native or genetically modified MSCs, as well as exosomal microRNAs (miRNAs), have been evaluated on CRC progression. Moreover, MSC-derived exosomes have been used as a carrier to deliver anticancer agents in colorectal cancer. In this review, we overview and discuss the current knowledge in both stem cell-based and cell-free exosome therapy of CRC. © 2022 Elsevier GmbH
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