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Tumor Antigens Publisher



Valilou SF1 ; Rezaei N2, 3, 4
Authors
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Authors Affiliations
  1. 1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2018


Abstract

Tumor antigens are the central factors in development of vaccines. They can be delivered to the body along with antigen presenting cells (APCs), immune simulators and immune modulators. Due to availability of new technology, the first gene recognized by T cell, was reported to encode a human tumor antigen and then rapidly molecular identification and characterization of novel tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs) including shared antigens, neoantigens, and unique antigens was developed. These antigens serve as a biomarker for identification of the tumor nature and developing novel cancer vaccines. In this chapter, we are going to discuss different types of tumor antigens such as shared and unique antigens and also other types of tumor antigens, including glycolipid- and glycoprotein-based tumor antigens, and provide their role in cancer vaccine development and cancer immunotherapy. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd All rights reserved.
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