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Does Choline Have an Effect on Transient Global Amnesia (Tga)? Publisher Pubmed



Rahmanian S1 ; Shapouri M2 ; Mohammadian MK3 ; Mahmoudi Z3 ; Saeedirad Z4 ; Mobarakeh KA5 ; Parhiz A6 ; Shekari S3 ; Harsini AR7 ; Valisoltani N7 ; Khoshdooz S8 ; Doaei S9 ; Kooshki A10 ; Gholamalizadeh M11
Authors
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Authors Affiliations
  1. 1. Nursing Faculty, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Kish International Campus, University of Tehran, Tehran, Iran
  7. 7. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  9. 9. Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Non-Communicable Diseases Research Center, Department of Nutrition and Biochemistry, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
  11. 11. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BMC Neuroscience Published:2024


Abstract

Background: Choline was frequently reported to have some beneficial effects on memory function. However, the association of dietary choline with different types of amnesia is not well understood. The objective of this study was to examine the association between dietary intake of choline and transient global amnesia (TGA). Methods: This case–control study was carried out on 258 patients with TGA and 520 participants without amnesia. Data on dietary choline intake was collected using a validated food frequency questionnaire (FFQ). All participants were examined for amnesia by a neurologist according to the Kaplan and Hodges criteria. Results: There was an inverse association between TGA and dietary choline intake after adjustment for age and gender (OR: 0.98, CI 95% 0.96–0.98, P = 0.03). The association remained significant after additional adjusting for physical activity, body mass index (BMI), occupation, marital status, smoking, and drinking alcohol (OR: 0.98, CI 95% 0.96–0.99, P = 0.04) and after further adjustment for calorie and food groups intake (OR: 0.98, CI 95% 0.96–0.99, P = 0.03). Conclusion: The results of this study indicated that choline may have beneficial effects against TGA. Further longitudinal studies are warranted. Graphical Abstract: (Figure presented.) © The Author(s) 2024.
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