Multiscale Technologies for Treatment of Ischemic Cardiomyopathy

Multiscale Technologies for Treatment of Ischemic Cardiomyopathy Publisher Pubmed

Mahmoudi M^{1, 2, 3} ; Yu M^{1, 2} ; Serpooshan V⁴ ; Wu JC^{4, 5, 6} ; Langer R⁷ ; Lee RT^{8, 9} ; Karp JM^{1, 10, 11, 12} ; Farokhzad OC^{1, 2, 3}

Show Affiliations

1. Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
2. Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
3. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran
4. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, United States
5. Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, 94305, CA, United States
6. Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, 94305, CA, United States
7. The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, 02139, MA, United States
8. Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, 02138, MA, United States
9. Department of Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Cambridge, 02138, MA, United States
10. Harvard-MIT Division of Health Sciences and Technology, Cambridge, 02139, MA, United States
11. Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
12. Harvard Stem Cell Institute, Cambridge, 02138, MA, United States

Source: Nature Nanotechnology Published:2017

Abstract

The adult mammalian heart possesses only limited capacity for innate regeneration and the response to severe injury is dominated by the formation of scar tissue. Current therapy to replace damaged cardiac tissue is limited to cardiac transplantation and thus many patients suffer progressive decay in the heart's pumping capacity to the point of heart failure. Nanostructured systems have the potential to revolutionize both preventive and therapeutic approaches for treating cardiovascular disease. Here, we outline recent advancements in nanotechnology that could be exploited to overcome the major obstacles in the prevention of and therapy for heart disease. We also discuss emerging trends in nanotechnology affecting the cardiovascular field that may offer new hope for patients suffering massive heart attacks. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

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Style	Citing Format
MLA	Mahmoudi M, et al.. "Multiscale Technologies for Treatment of Ischemic Cardiomyopathy." Nature Nanotechnology, vol. 12, no. 9, 2017, pp. 845-855.
APA	Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC (2017). Multiscale Technologies for Treatment of Ischemic Cardiomyopathy. Nature Nanotechnology, 12(9), 845-855.
Chicago	Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. "Multiscale Technologies for Treatment of Ischemic Cardiomyopathy." Nature Nanotechnology 12, no. 9 (2017): 845-855.
Harvard	Mahmoudi M et al. (2017) 'Multiscale Technologies for Treatment of Ischemic Cardiomyopathy', Nature Nanotechnology, 12(9), pp. 845-855.
Vancouver	Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, et al.. Multiscale Technologies for Treatment of Ischemic Cardiomyopathy. Nature Nanotechnology. 2017;12(9):845-855.
BibTex	@article{ author = {Mahmoudi M and Yu M and Serpooshan V and Wu JC and Langer R and Lee RT and Karp JM and Farokhzad OC}, title = {Multiscale Technologies for Treatment of Ischemic Cardiomyopathy}, journal = {Nature Nanotechnology}, volume = {12}, number = {9}, pages = {845-855}, year = {2017} }
RIS	TY - JOUR AU - Mahmoudi M AU - Yu M AU - Serpooshan V AU - Wu JC AU - Langer R AU - Lee RT AU - Karp JM AU - Farokhzad OC TI - Multiscale Technologies for Treatment of Ischemic Cardiomyopathy JO - Nature Nanotechnology VL - 12 IS - 9 SP - 845 EP - 855 PY - 2017 ER -

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