Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity

Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity Publisher Pubmed

Rahmani S¹ ; Mohammadi Z² ; Amini M³ ; Isaei E⁴ ; Taheritarigh S⁵ ; Rafiee Tehrani N⁶ ; Rafiee Tehrani M⁷

Show Affiliations

1. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Microbiology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
5. Department of Plant Breeding and Biotechnology, Faculty of Plant Production, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
6. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Departments of Pharmaceutics, Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Carbohydrate Polymers Published:2016

Abstract

Chitosan, as a biocompatible polymer, is very attractive for biomedical applications. Continues studies are performing for improving its physicochemical features in order to make it more suitable for such approaches. In this study, methylated 4-N,N dimethyl aminobenzyl N,O carboxymethyl chitosan (MABCC) was synthesized,as a new chitosan derivative, in three steps. The investigations were carried out using FTIR, NMR, TGA and zeta potential measurement. Antibacterial and cell viability assessments were performed on four bacterial strains and two cell lines respectively. FTIR and NMR results showed that all substitution reactions were successfully carried out. Zeta potential of MABCC at various pH especially alkaline pH was greater than chitosan and it revealed increasing the solubility of the derivative. Antibacterial activity of MABCC was extremely greater than chitosan especially in Gram positive bacteria.Furthermore,it had no significant cytotoxicity against MCF-7 and Skov-3 cell lines in comparison to chitosan. These findings confirm that this new derivative can be introduced as a suitable compound for biomedical purposes. © 2016 Elsevier Ltd. All rights reserved.

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Farid Dorkoosh (2)

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Style	Citing Format
MLA	Rahmani S, et al.. "Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity." Carbohydrate Polymers, vol. 149, no. , 2016, pp. 131-139.
APA	Rahmani S, Mohammadi Z, Amini M, Isaei E, Taheritarigh S, Rafiee Tehrani N, Rafiee Tehrani M (2016). Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity. Carbohydrate Polymers, 149(), 131-139.
Chicago	Rahmani S, Mohammadi Z, Amini M, Isaei E, Taheritarigh S, Rafiee Tehrani N, Rafiee Tehrani M. "Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity." Carbohydrate Polymers 149, no. (2016): 131-139.
Harvard	Rahmani S et al. (2016) 'Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity', Carbohydrate Polymers, 149(), pp. 131-139.
Vancouver	Rahmani S, Mohammadi Z, Amini M, Isaei E, Taheritarigh S, Rafiee Tehrani N, et al.. Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity. Carbohydrate Polymers. 2016;149():131-139.
BibTex	@article{ author = {Rahmani S and Mohammadi Z and Amini M and Isaei E and Taheritarigh S and Rafiee Tehrani N and Rafiee Tehrani M}, title = {Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity}, journal = {Carbohydrate Polymers}, volume = {149}, number = {}, pages = {131-139}, year = {2016} }
RIS	TY - JOUR AU - Rahmani S AU - Mohammadi Z AU - Amini M AU - Isaei E AU - Taheritarigh S AU - Rafiee Tehrani N AU - Rafiee Tehrani M TI - Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity JO - Carbohydrate Polymers VL - 149 IS - SP - 131 EP - 139 PY - 2016 ER -

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