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Crosstalk Between Chitosan and Cell Signaling Pathways Publisher Pubmed



Farhadihosseinabadi B1 ; Zarebkohan A2, 3 ; Eftekhary M1 ; Heiat M4 ; Moosazadeh Moghaddam M5 ; Gholipourmalekabadi M6, 7
Authors
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Authors Affiliations
  1. 1. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran
  3. 3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Cellular and Molecular Life Sciences Published:2019


Abstract

The field of tissue engineering (TE) experiences its most exciting time in the current decade. Recent progresses in TE have made it able to translate into clinical applications. To regenerate damaged tissues, TE uses biomaterial scaffolds to prepare a suitable backbone for tissue regeneration. It is well proven that the cell–biomaterial crosstalk impacts tremendously on cell biological activities such as differentiation, proliferation, migration, and others. Clarification of exact biological effects and mechanisms of a certain material on various cell types promises to have a profound impact on clinical applications of TE. Chitosan (CS) is one of the most commonly used biomaterials with many promising characteristics such as biocompatibility, antibacterial activity, biodegradability, and others. In this review, we discuss crosstalk between CS and various cell types to provide a roadmap for more effective applications of this polymer for future uses in tissue engineering and regenerative medicine. © 2019, Springer Nature Switzerland AG.
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