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In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles Publisher Pubmed

Summary: Curious about cancer treatment advancements? Study shows miRNA-206 is more effective than dual miRNA-143 & 206 in inducing apoptosis in EL4 cancer cells. What implications does this have for therapies? #CancerTreatment #MiRNA

Shams A1, 2 ; Shabani R1, 2 ; Asgari H2 ; Karimi M3 ; Najafi M4 ; Asgharijafarabadi M5, 6 ; Razavi SM7 ; Miri SR8 ; Abbasi M9 ; Mohammadi A2 ; Koruji M1, 2
Authors

Source: Nanomedicine Published:2022


Abstract

Aim: MiRNA's-143 and-206 are powerful apoptotic regulators in cancer cells. This study aimed to use miRNA-143- A nd 206-loaded poly(lactic-co-glycolic) acid (PLGA) nanoparticles conjugated with folic acid to induce apoptosis in the EL4 cancer cells. Materials & methods: The therapy was conducted in six groups: Treatment with both miRNAs simultaneously (mixed miRNAs), miRNA-206 treatment, miRNA-143 treatment, blank PLGA, blank polyethylenimine (PEI) and complex PEI-miRNAs. Results: In terms of viability, in mixed miRNAs no synergistic effect was observed on EL4 cell elimination. However, in the single miRNA-206 group, a stronger apoptotic effect was observed than the mixed miRNAs group and single miRNA-143 group alone. Conclusion: MiRNAs' apoptotic induction effects in cancer cells were found to be remarkable. © 2022 Future Medicine Ltd.
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