Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Microrna-Induced Apoptosis in Diverse Radioresistant Cancers Publisher Pubmed



Darvish L1 ; Bahreyni Toossi MT2 ; Azimian H1, 2 ; Shakeri M3, 4 ; Dolat E1 ; Ahmadizad Firouzjaei A5 ; Rezaie S6 ; Amraee A7 ; Aghaeebakhtiari SH6, 8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Medical Physics, Faculty of Medicine, School of Medicine, Lorestan University of Medical Sciences, khorramabad, Iran
  8. 8. Bioinformatics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Cellular Signalling Published:2023


Abstract

Resistance to cancer radiotherapy is one of the biggest concerns for success in treating and preventing recurrent disease. Malignant tumors may develop when they block genetic mutations associated with apoptosis or abnormal expression of apoptosis; Tumor treatment may induce the expression of apoptosis-related genes to promote tumor cell apoptosis. MicroRNAs have been shown to contribute to forecasting prognosis, distinguishing between cancer subtypes, and affecting treatment outcomes in cancer. Constraining these miRNAs may be an attractive treatment strategy to help overcome radiation resistance. The delivery of these future treatments is still challenging due to the excess downstream targets that each miRNA can control. Understanding the role of miRNAs brings us one step closer to attaining patient treatment and improving patient outcomes. This review summarized the current information on the role of microRNA-induced apoptosis in determining the radiosensitivity of various cancers. © 2022
Related Docs
View other Related Docs
1. Application of Nano-Radiosensitizers in Combination Cancer Therapy, Bioengineering and Translational Medicine (2023)
2. Differential Mirnas Expression Pattern of Irradiated Breast Cancer Cell Lines Is Correlated With Radiation Sensitivity, Scientific Reports (2020)
3. To Be or Not to Be: Navigating the Influence of Micrornas on Cervical Cancer Cell Death, Cancer Cell International (2025)
4. Effects of Micrornas and Long Non-Coding Rnas on Chemotherapy Response in Glioma, Epigenomics (2022)
5. Modulation of Apoptosis by Melatonin for Improving Cancer Treatment Efficiency: An Updated Review, Life Sciences (2019)
6. The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy, Journal of Biomedical Science (2016)
7. Micrornas As Biomarkers for Early Diagnosis, Targeting and Prognosis of Prostate Cancer, Pathology Research and Practice (2023)
8. Micro-Rnas As Critical Regulators of Matrix Metalloproteinases in Cancer, Journal of Cellular Biochemistry (2018)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Jamshidi (2)
Mahdi Mahmoudi (2)
Other Related Docs
9. Role of Mirnas in Apoptosis Pathways of Immune Cells in Systemic Lupus Erythematosus, Immunity, Inflammation and Disease (2025)
10. Overexpression of Microrna-16 Declines Cellular Growth, Proliferation and Induces Apoptosis in Human Breast Cancer Cells, In Vitro Cellular and Developmental Biology - Animal (2015)
11. Stat3 Targeting by Polyphenols: Novel Therapeutic Strategy for Melanoma, BioFactors (2017)
12. Micrornas and Exosomes: Cardiac Stem Cells in Heart Diseases, Pathology Research and Practice (2022)
13. Effects of Noncoding Rnas in Radiotherapy Response in Breast Cancer: A Systematic Review, Cell Cycle (2022)
14. The Role of Oncomirs in the Pathogenesis and Treatment of Breast Cancer, Biomedicine and Pharmacotherapy (2016)
15. Inhibition of Microrna-21 Induces Apoptosis in Dermal Fibroblasts of Patients With Systemic Sclerosis, International Journal of Dermatology (2016)
16. Resveratrol As an Adjuvant for Normal Tissues Protection and Tumor Sensitization, Current Cancer Drug Targets (2020)
17. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)
18. Cancer Genetics at a Glance: The Comprehensive Insights, Cancer Genetics and Psychotherapy (2017)
19. The Role of Mir-29A and Mir-143 on the Anti-Apoptotic Mcl-1/Ciap-2 Genes Expression in Egfr Mutated Non-Small Cell Lung Carcinoma Patients, Biochemical Genetics (2024)
20. Recent Advances in Mesenchymal Stem Cell Therapy for Multiple Sclerosis: Clinical Applications and Challenges, Frontiers in Cell and Developmental Biology (2025)
21. Resveratrol As an Enhancer of Apoptosis in Cancer: A Mechanistic Review, Anti-Cancer Agents in Medicinal Chemistry (2021)
22. Mirnas and Exosomal Mirnas in Lung Cancer: New Emerging Players in Tumor Progression and Therapy Response, Pathology Research and Practice (2023)
23. The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms, Frontiers in Pharmacology (2023)
24. Microrna-Induced Drug Resistance in Gastric Cancer, Biomedicine and Pharmacotherapy (2015)
25. A Bioinformatics Approach to the Identification of Variants Associated With Type 1 and Type 2 Diabetes Mellitus That Reside in Functionally Validated Mirnas Binding Sites, Biochemical Genetics (2016)
26. Autophagy in Cancers Including Brain Tumors: Role of Micrornas, Cell Communication and Signaling (2020)