All Solid Sate Potentiometric Sensors for the Measurement of Paroxetine in Pharmaceutical Formulation



Faridbod F^{1, 2} ; Davarkhah N¹ ; Karamdoust S¹
Source: International Journal of Electrochemical Science Published:2015

Abstract

One of the selective serotonin reuptake inhibitors (SSRIs) is Paroxetine which is used as an antidepressant compound. A PVC membrane electrode (PME), as a symmetric potentiometric sensor and all solid state polymeric membrane electrode (ASS-PME) as an asymmetric sensor were made and used for determination of Paroxetine in pharmaceutical tablets. The sensing element of two kinds of sensor was an ion-pair compound. The finest membrane was composed of 7% PAX-tetrakis (p-chlorophenyl) borate as sensing element, 59% dibutyl sebacate as a solvent mediator, 30% poly(vinyl chloride) as polymeric matrix, 2% ionic liquid and 2% KpClTPB as an ionic additive. The all solid state electrode is made of a conductive composite of graphite, MWCNTs, and epoxy resin on a copper wire. A thin layer of PVC membrane is then coated on the surface of the new conducting transducer. The Nernstian behavior (slope of 57.8±0.3 mV/decade in case of PME and 58.6±0.3 mV/decade) can be seen in a wide concentration range of 7.5×10-6 to 1.0×10-1 mol L-1 for PME, 8.0×10-8 to 1.0×10-3 mol L-1 for ASSME. Method validation parameters were calculated and can be used in quality control analysis of Paroxetine hydrochloride in pharmaceutical formulations. The sensors were successfully used for measurement of the active ingredient of Paroxetine tablets. © 2015 The Authors.