Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide

Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide Publisher

Saeedi M^{1, 2} ; Hashemi M³ ; Mahdavi M⁴ ; Rafinejad A³ ; Najafi Z⁵ ; Mirfazli SS⁶ ; Mohammadian R⁷ ; Karimpourrazkenari E² ; Kabudanian Ardestani S⁷ ; Safavi M⁸ ; Akbarzadeh T^{2, 3}

Show Affiliations

1. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, School of pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
6. Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran
7. Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
8. Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran

Source: Polycyclic Aromatic Compounds Published:2020

Abstract

In this study, a new series of N-(di or trimethoxyaryl)-5-arylisoxazole-3-carboxamide derivatives were synthesized and evaluated against human breast cancer cell lines including MCF-7, MDA-MB-231, and T-47D. Among the synthesized compounds, 5-(m-tolyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide (8f) showed significant cytotoxicity against all three cell lines comparing with etoposide as the reference drug. Also, Annexin V-FITC/propidium iodide and acridine orange/ethidium bromide staining assay were performed to validate apoptotic activity of compound 8f. The results confirmed induction of apoptosis at early stage. © 2019 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Saeedi M, et al.. "Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide." Polycyclic Aromatic Compounds, vol. 40, no. 5, 2020, pp. 1568-1580.
APA	Saeedi M, Hashemi M, Mahdavi M, Rafinejad A, Najafi Z, Mirfazli SS, Mohammadian R, Karimpourrazkenari E, Kabudanian Ardestani S, Safavi M, Akbarzadeh T (2020). Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide. Polycyclic Aromatic Compounds, 40(5), 1568-1580.
Chicago	Saeedi M, Hashemi M, Mahdavi M, Rafinejad A, Najafi Z, Mirfazli SS, Mohammadian R, et al.. "Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide." Polycyclic Aromatic Compounds 40, no. 5 (2020): 1568-1580.
Harvard	Saeedi M et al. (2020) 'Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide', Polycyclic Aromatic Compounds, 40(5), pp. 1568-1580.
Vancouver	Saeedi M, Hashemi M, Mahdavi M, Rafinejad A, Najafi Z, Mirfazli SS, et al.. Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide. Polycyclic Aromatic Compounds. 2020;40(5):1568-1580.
BibTex	@article{ author = {Saeedi M and Hashemi M and Mahdavi M and Rafinejad A and Najafi Z and Mirfazli SS and Mohammadian R and Karimpourrazkenari E and Kabudanian Ardestani S and Safavi M and Akbarzadeh T}, title = {Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide}, journal = {Polycyclic Aromatic Compounds}, volume = {40}, number = {5}, pages = {1568-1580}, year = {2020} }
RIS	TY - JOUR AU - Saeedi M AU - Hashemi M AU - Mahdavi M AU - Rafinejad A AU - Najafi Z AU - Mirfazli SS AU - Mohammadian R AU - Karimpourrazkenari E AU - Kabudanian Ardestani S AU - Safavi M AU - Akbarzadeh T TI - Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide JO - Polycyclic Aromatic Compounds VL - 40 IS - 5 SP - 1568 EP - 1580 PY - 2020 ER -

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