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Nanostructures for Site-Specific Delivery of Oxaliplatin Cancer Therapy: Versatile Nanoplatforms in Synergistic Cancer Therapy Publisher



Bagheri M1 ; Zandieh MA2 ; Daryab M3 ; Samaei SS4 ; Gholami S5 ; Rahmanian P4 ; Dezfulian S4 ; Eary M4 ; Rezaee A6 ; Rajabi R4 ; Khorrami R7 ; Salimimoghadam S8 ; Hu P9 ; Rashidi M10, 11 Show All Authors
Authors
  1. Bagheri M1
  2. Zandieh MA2
  3. Daryab M3
  4. Samaei SS4
  5. Gholami S5
  6. Rahmanian P4
  7. Dezfulian S4
  8. Eary M4
  9. Rezaee A6
  10. Rajabi R4
  11. Khorrami R7
  12. Salimimoghadam S8
  13. Hu P9
  14. Rashidi M10, 11
  15. Ardakan AK4
  16. Ertas YN12, 13
  17. Hushmandi K2
Show Affiliations
Authors Affiliations
  1. 1. Radiology Resident, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
  5. 5. Young Researcher and Elite Club, Babol Branch, Islamic Azad University, Babol, Iran
  6. 6. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  8. 8. Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  9. 9. Department of Emergency, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China
  10. 10. Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  11. 11. The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  12. 12. Department of Biomedical Engineering, Erciyes University, Kayseri, Turkey
  13. 13. ERNAM–Nanotechnology Research and Application Center, Erciyes University, Kayseri, Turkey

Source: Translational Oncology Published:2024


Abstract

As a clinically approved treatment strategy, chemotherapy-mediated tumor suppression has been compromised, and in spite of introducing various kinds of anticancer drugs, cancer eradication with chemotherapy is still impossible. Chemotherapy drugs have been beneficial in improving the prognosis of cancer patients, but after resistance emerged, their potential disappeared. Oxaliplatin (OXA) efficacy in tumor suppression has been compromised by resistance. Due to the dysregulation of pathways and mechanisms in OXA resistance, it is suggested to develop novel strategies for overcoming drug resistance. The targeted delivery of OXA by nanostructures is described here. The targeted delivery of OXA in cancer can be mediated by polymeric, metal, lipid and carbon nanostructures. The advantageous of these nanocarriers is that they enhance the accumulation of OXA in tumor and promote its cytotoxicity. Moreover, (nano)platforms mediate the co-delivery of OXA with drugs and genes in synergistic cancer therapy, overcoming OXA resistance and improving insights in cancer patient treatment in the future. Moreover, smart nanostructures, including pH-, redox-, light-, and thermo-sensitive nanostructures, have been designed for OXA delivery and cancer therapy. The application of nanoparticle-mediated phototherapy can increase OXA's potential in cancer suppression. All of these subjects and their clinical implications are discussed in the current review. © 2023
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