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Micrornas Signatures, Bioinformatics Analysis of Mirnas, Mirna Mimics and Antagonists, and Mirna Therapeutics in Osteosarcoma Publisher



Otoukesh B1, 2 ; Abbasi M3 ; Gorgani HOL2 ; Farahini H2 ; Moghtadaei M2 ; Boddouhi B2 ; Kaghazian P4 ; Hosseinzadeh S5 ; Alaee A6
Authors
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Authors Affiliations
  1. 1. Orthopedic Surgery Fellowship in Departement Hospitalo, Universitaire Mamuth Maladies Musculo-squelettiques et Innovations Therapeutiques, Universite Pierre et Marie-Curie, Sorbonne Universite, Paris, France
  2. 2. Department of Orthopedic Surgery, Bone and Joint Reconstruction Research Center, Iran University of Medical Science, Tehran, 1445613131, Iran
  3. 3. Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Orthopedic and Traumatology, Universitatsklinikum Bonn, Bonn, Germany
  5. 5. Department of Orthopedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States
  6. 6. Department of Information Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Cell International Published:2020


Abstract

MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted. © 2020 The Author(s).
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