Frequency of Inducible Clindamycin Resistance and Analysis of Multi-Resistant Antibiotic Profile of Methicillin-Resistant Staphylococcus Aureus



Bidarigh Z¹ ; Pourmand MR² ; Mashhadi R³ Show Affiliations
Source: Journal of Mazandaran University of Medical Sciences Published:2015

Abstract

Background and purpose: Clindamycin is used in treatment of common infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Constitutive or inducible resistance of clindamycin are important factors in choosing that as an effective antibiotic. The aims of this study were to determine inducible resistance clindamycin and analysis of multiple antibiotic resistance profile in clinical isolates of MRSA. Materials and methods: Identification of 250 clinical Staphylococcus aureus isolates was carried out using biochemical and molecular methods. After determining the sensitivity to erythromycin, constitutive or inducible clindamycin resistance were detected by D test according to CLSI guidelines. Results: Out of 250 clinical Staphylococcus aureus isolates, 130 isolates (52%) were resistant to methicillin. Among them, 118 isolates (90.8%) were resistant to erythromycin. Moreover, 105 (88.9%), 9(7.6%) and 4 (3.3%) isolates were identified as constitutive and inducible resistance to clindamycin and MS phenotype, respectively. Conclusion: Inappropriate antibiotic therapy in MRSA infections leads to development of constitutive resistance and treatment failure. Also, due to increasing constitutive resistance in MRSA isolates, performing D test is essential to distinguish the constitutive and inducible resistance and selecting the best treatment. © 2015, Mazandaran University of Medical Sciences. All rights reserved.