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Design and Synthesis of a Biocompatible 1D Coordination Polymer As Anti-Breast Cancer Drug Carrier, 5-Fu: In Vitro and in Vivo Studies Publisher Pubmed



Rezaei M1 ; Abbasi A1 ; Dinarvand R2, 3 ; Jedditehrani M4 ; Janczak J5
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Tehran, 14155-6455, Iran
  2. 2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176-14411, Iran
  3. 3. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176-14411, Iran
  4. 4. Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, 19615-1177, Iran
  5. 5. Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, Wroclaw, 50-950, Poland

Source: ACS Applied Materials and Interfaces Published:2018


Abstract

Designable coordination polymers with suitable chemical diversities and biocompatible structures have been proposed as a promising class of vehicles for drug delivery systems. Here, we hydrothermally synthesized a novel one-dimensional (1D) coordination polymer, [Zn(H2O)6K2(H2BTC)2(H2O)4](H2BTC)2·2H2O, where H3BTC = benzene-1,3,5-tricarboxylic acid (trimesic acid), cp.1. As the hydrogen bonds stabilized 1D chains in three dimensions, the cp.1 could be a good candidate for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu). The synthesized cp.1 showed a remarkable 5-Fu loading of 66% with encapsulation efficiency of 98% and almost complete release process. The 5-Fu-loaded cp.1 displayed a time-dependent cytotoxicity effect against breast cancer cell lines MCF-7 and 4T1. The cellular uptake of cp.1 particles was investigated via confocal laser scanning microscopy using fluorescein isothiocyanate and LysoTracker Red staining. Furthermore, the in vivo antitumor impact of 5-Fu-loaded cp.1 was studied on 4T1 breast cancer BALB/c mice model. The intratumor treatment of 5-Fu-loaded cp.1 demonstrated beneficial antitumor efficacy by postponing tumor growth. These results suggest that the 5-Fu-loaded cp.1 microparticles with a great locoregional delivery can be efficient anticancer drug carriers for further clinical treatments. © 2018 American Chemical Society.