Electroactive Nanofibrous Scaffold Based on Polythiophene for Bone Tissue Engineering Application Publisher



Vandghanooni S¹ ; Samadian H² ; Akbarinakhjavani S³ ; Khalilzadeh B^{4, 5} ; Eskandani M⁶ ; Massoumi B⁷ ; Jaymand M⁸ Show Affiliations
Source: Journal of Materials Research Published:2022

Abstract

Electrically conductive polymeric biomaterials are promising candidates for bone tissue engineering (TE) due to pivotal role of electrical stimulation (ES) in regulating of some biological functions, including cell's adhesion, migration and differentiation, as well as DNA synthesis. Herein, we have designed and developed a conductive nanofibrous scaffold composed of poly(vinyl amine) (PVAm), polythiophene (PTh), and poly(ε-caprolactone) (PCL), and its performance in bone TE was preliminary investigated in terms of some physicochemical as well as biological properties. Electrical conductivity of the produced scaffold was determined as 5.7 × 10–3 Scm−1. The fabricated scaffold in acidic condition exhibited higher biodegradation rate (pH 4.2; 40.1 wt%) than the physiological condition (PBS; pH 7.4; 33.6 wt%). MTT assay results revealed that the fabricated scaffold has an acceptable biocompatibility and can improve the cell's adhesion as well as proliferation that qualified it for a successful TE process. Graphical abstract: Nanofibrous electrically conductive scaffold composed of poly(vinyl amine) (PVAm), polythiophene (PTh), and poly(ε-caprolactone) (PCL) was developed through electrospinning technique, and its performance in bone TE was preliminary investigated in terms of some physicochemical as well as biological features. [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to The Materials Research Society.