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Maternal Vitamin D Supplementation and Treadmill Exercise Attenuated Vitamin D Deficiency-Induced Anxiety-And Depressive-Like Behaviors in Adult Male Offspring Rats Publisher Pubmed



Kazemi F1 ; Babri S1 ; Keyhanmehr P1 ; Faridhabibi M1 ; Rad SN2 ; Farajdokht F3
Authors
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Authors Affiliations
  1. 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Nutritional Neuroscience Published:2023


Abstract

Background: Vitamin D is a vital neuroactive steroid for brain development and function. Vitamin D deficiency is a worldwide health problem, particularly in children and women. Gestational or developmental vitamin D deficiency is associated with an increased risk of neurodevelopmental and neuropsychiatric disorders. This study examined the effect of maternal vitamin D dietary manipulations and treadmill exercise on anxiety-and depressive-related behaviors, pro-inflammatory cytokines, and prefrontal cortex (PFC) protein levels of brain-derived neurotrophic factor (BDNF) and vitamin D receptor (VDR) in adult male offspring born to vitamin D-deficient diet (VDD)-fed dams. Methods and Results: Female rats were provided standard diet (SD) or VDD for six weeks and then were treated with SD (started a week before mating throughout gestation and lactation) and treadmill exercise (a week before mating until gestational day 20). Male offspring were separated on postnatal day (PND) 21 and fed SD chow until PND90. Our results demonstrated that maternal vitamin D deficiency increased anxiety and depression-related behaviors, increased levels of TNF-α and IL-1β in serum, and decreased prefrontal protein expressions of BDNF and VDR in adult male offspring. However, maternal vitamin D supplementation and treadmill exercise reversed these changes alone or in combination. Conclusion: It seems that developmental vitamin D deficiency disrupts brain development and has a long-lasting effect on VDR and BDNF signaling in the rat brain resulting in neuropsychiatric disorders in offspring. Therefore, vitamin D supplementation and physical exercise are reasonable strategies to prevent these neurobehavioral impairments. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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