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The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Breast Cancer and Dietary Intake Publisher Pubmed



Doaei S1 ; Abdollahi S2 ; Mohseni GK3 ; Gholamalizadeh M4 ; Akbari ME4 ; Poorhosseini SM5 ; Bagheri SE6, 7 ; Ghafourifard S5 ; Tabesh GA5 ; Moslem A8 ; Hasanpour Ardekanizadeh N9 ; Omidi S10 ; Hekmatdoost A11 ; Alam Rajabi M12 Show All Authors
Authors
  1. Doaei S1
  2. Abdollahi S2
  3. Mohseni GK3
  4. Gholamalizadeh M4
  5. Akbari ME4
  6. Poorhosseini SM5
  7. Bagheri SE6, 7
  8. Ghafourifard S5
  9. Tabesh GA5
  10. Moslem A8
  11. Hasanpour Ardekanizadeh N9
  12. Omidi S10
  13. Hekmatdoost A11
  14. Alam Rajabi M12
  15. Mosavi Jarrahi SA4
  16. Goodarzi MO13
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Nutrition & Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Genomic Research Center, Department of Medical Genetic, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Master Student of Epidemiology, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  7. 7. Nurse Anesthesia, Guilan University of Medical Sciences (GUMS), Langroud, Iran
  8. 8. Department of Anesthesiology, Sabzevar University of Medical Sciences, Sabzevar, Iran
  9. 9. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Department of Health Education and Promotion, Research Center of Health and Environment, School of Health, Guilan University of Medical Sciences, Rasht, Iran
  11. 11. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Department of Pathology, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran
  13. 13. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Source: Journal of Cellular and Molecular Medicine Published:2022


Abstract

Breast cancer (BC) is the leading cause of cancer-related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity-associated (FTO) single-nucleotide polymorphisms (SNPs) and BC. This study aimed to investigate the impact of FTO rs9939609 polymorphism on the association between BC and dietary intake. This study was conducted on 180 women with BC as the case group and 360 healthy women as the control group. The dietary intakes were assessed by a valid 168-item food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. After adjusting the confounding variables, there was no significant association between dietary intake and BC in individuals without risk allele. A positive association between dietary intake of omega-6 fatty acids and BC was found only in individuals with risk allele of FTO gene (OR: 1.31, 95% CI: 1.08–1.60, p: 0.006). FTO gene risk allele may influence the effect of diet on breast cancer risk. Further studies are needed to assess the possible effects of the FTO genotype on the association between BC risk and dietary components. © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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