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The Case for Simplifying and Using Absolute Targets for Viral Hepatitis Elimination Goals Publisher Pubmed



Razavi H1 ; Blach S1 ; Razavishearer D1 ; Abaalkhail F2 ; Abbas Z3 ; Abdallah A4 ; Abrao Ferreira P5 ; Abu Raddad LJ6 ; Adda D7 ; Agarwal K8 ; Aghemo A9 ; Ahmed A10 ; Albusafi SA11 ; Alhamoudi W12 Show All Authors
Authors
  1. Razavi H1
  2. Blach S1
  3. Razavishearer D1
  4. Abaalkhail F2
  5. Abbas Z3
  6. Abdallah A4
  7. Abrao Ferreira P5
  8. Abu Raddad LJ6
  9. Adda D7
  10. Agarwal K8
  11. Aghemo A9
  12. Ahmed A10
  13. Albusafi SA11
  14. Alhamoudi W12
  15. Alkaabi S13
  16. Alromaihi H14
  17. Aljarallah B15
  18. Alnaamani K16
  19. Alqahtani S17
  20. Alswat K18
  21. Altraif I19
  22. Asselah T20
  23. Bacon B21
  24. Bessone F22
  25. Bizri AR23
  26. Block T24
  27. Bonino F25
  28. Brandaomello CE26
  29. Brown K27
  30. Bruggmann P28
  31. Brunetto MR29
  32. Buti M30
  33. Cabezas J31
  34. Calleja JL32
  35. Castro Batanjer E33
  36. Chan HLY34
  37. Chang H35
  38. Chen CJ36
  39. Christensen PB37
  40. Chuang WL38
  41. Cisneros L39
  42. Cohen C24
  43. Colombo M40
  44. Conway B41
  45. Cooper C42
  46. Craxi A43
  47. Crespo J44, 45
  48. Croes E46
  49. Cryer D47
  50. Cupertino De Barros FP48
  51. Derbala M13
  52. Dillon J49
  53. Doss W50
  54. Dou X51
  55. Doyle J52
  56. Duberg AS53
  57. Dugan E1
  58. Dunn R1
  59. Dusheiko G54
  60. El Khayat H55
  61. Elsayed MH56
  62. Eshraghian A57
  63. Esmat G50
  64. Esteban Mur R30
  65. Ezzat S4
  66. Falconer K58
  67. Fassio E59
  68. Ferrinho P60
  69. Flamm S61
  70. Flisiak R62
  71. Foster G63
  72. Fung J64
  73. Garciasamaniego J65
  74. Gish RG66
  75. Goncales F67
  76. Halota W68
  77. Hamoudi W69
  78. Hassany M70
  79. Hatzakis A71
  80. Hay S72
  81. Himatt S73
  82. Hoepelman IM74
  83. Hsu YC75
  84. Hui YT76
  85. Hunyady B77
  86. Jacobson I78
  87. Janjua N79
  88. Janssen H80
  89. Jarcuska P81
  90. Kabagambe K82
  91. Kanto T83
  92. Kao JH84
  93. Kaymakoglu S85
  94. Kershenobich D86
  95. Khamis F87
  96. Kim DJ88, 89
  97. Kim DY90
  98. Kondili LA91
  99. Kottilil S92
  100. Kramvis A93
  101. Kugelmas M94
  102. Kurosaki M95
  103. Lacombe K96
  104. Lagging M97
  105. Lao WC98
  106. Lavanchy D99
  107. Lazarus JV100
  108. Lee A101
  109. Lee SS102
  110. Levy M103
  111. Liakina V104, 105
  112. Lim YS106
  113. Liu S107
  114. Maddrey W108
  115. Malekzadeh R109
  116. Marinho RT110
  117. Mathur P92
  118. Maticic M111
  119. Mendes Correa MC112
  120. Mera J113
  121. Merat S114
  122. Mogawer S50
  123. Mohamed R115
  124. Muellhaupt B116
  125. Muljono D117
  126. Mostafa I118
  127. Nahum MS119
  128. Nawaz A120
  129. Negro F121
  130. Ninburg M122
  131. Ning Q123
  132. Ntiri Reid B124
  133. Nymadawa P125
  134. Oevrehus A126
  135. Ormeci N127
  136. Orrego M128
  137. Osman A4
  138. Oyunsuren T129
  139. Pan C130
  140. Papaevangelou V131
  141. Papatheodoridis G71
  142. Popping S132
  143. Prasad P133
  144. Prithiviputh R134
  145. Qureshi H135
  146. Ramji A136
  147. Razavishearer K1
  148. Reddy R137
  149. Remak W138
  150. Richter C139
  151. Ridruejo E140
  152. Robaeys G141, 142, 143
  153. Roberts S144
  154. Roberts L145
  155. Roudotthoraval F146
  156. Saab S147
  157. Said S148
  158. Salamat A149
  159. Sanai F150
  160. Sanchezavila JF151
  161. Schiff E152
  162. Schinazi R153
  163. Sebastiani G154
  164. Seguindevaux C155
  165. Shanmugam RP156
  166. Sharara A157
  167. Shilton S158
  168. Shouval D159
  169. Sievert W160
  170. Simonova M161
  171. Sohrabpour AA162, 163
  172. Sonderup M164
  173. Soza A165
  174. Wendy Spearman C164
  175. Steinfurth N166
  176. Sulkowski M17
  177. Tan SS165
  178. Tanaka J166
  179. Tashi D167
  180. Thein HH168
  181. Thompson P169
  182. Tolmane I170
  183. Toy M171
  184. Valantinas J172
  185. Van De Vijver D173
  186. Velezmoller P174
  187. Vince A175
  188. Waked I4
  189. Wang S176
  190. Wedemeyer H177
  191. Wong V178
  192. Xie Q179
  193. Yamada S180
  194. Yang HI181
  195. Yesmembetov K182
  196. Yilmaz Y183
  197. Younossi Z184
  198. Yu ML185
  199. Yuen MF186
  200. Yurdaydin C187
  201. Yusuf A188
  202. Zekry A189
  203. Zeuzem S190

Source: Journal of Viral Hepatitis Published:2021


Abstract

The 69th World Health Assembly endorsed the Global Health Sector Strategy for Viral Hepatitis, embracing a goal to eliminate hepatitis infection as a public health threat by 2030. This was followed by the World Health Organization's (WHO) global targets for the care and management of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These announcements and targets were important in raising awareness and calling for action; however, tracking countries’ progress towards these elimination goals has provided insights to the limitations of these targets. The existing targets compare a country's progress relative to its 2015 values, penalizing countries who started their programmes prior to 2015, countries with a young population, or countries with a low prevalence. We recommend that (1) WHO simplify the hepatitis elimination targets, (2) change to absolute targets and (3) allow countries to achieve these disease targets with their own service coverage initiatives that will have the maximum impact. The recommended targets are as follows: reduce HCV new chronic cases to ≤5 per 100 000, reduce HBV prevalence among 1-year-olds to ≤0.1%, reduce HBV and HCV mortality to ≤5 per 100 000, and demonstrate HBV and HCV year-to-year decrease in new HCV- and HBV-related HCC cases. The objective of our recommendations is not to lower expectations or diminish the hepatitis elimination standards, but to provide clearer targets that recognize the past and current elimination efforts by countries, help measure progress towards true elimination, and motivate other countries to follow suit. © 2020 John Wiley & Sons Ltd
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