The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013

The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013 Publisher Pubmed

Stanaway JD¹ ; Flaxman AD¹ ; Naghavi M¹ ; Fitzmaurice C^{1, 2} ; Vos T¹ ; Abubakar I³ ; Aburaddad LJ⁴ ; Assadi R⁵ ; Bhala N^{6, 7} ; Cowie B^{8, 9} ; Forouzanfour MH¹ ; Groeger J¹⁰ ; Hanafiah KM^{11, 12} ; Jacobsen KH¹³ Show All Authors

Stanaway JD¹
Flaxman AD¹
Naghavi M¹
Fitzmaurice C^{1, 2}
Vos T¹
Abubakar I³
Aburaddad LJ⁴
Assadi R⁵
Bhala N^{6, 7}
Cowie B^{8, 9}
Forouzanfour MH¹
Groeger J¹⁰
Hanafiah KM^{11, 12}
Jacobsen KH¹³
James SL¹⁴
Maclachlan J^{8, 9}
Malekzadeh R¹⁵
Martin NK^{16, 17}
Mokdad AA¹⁸
Mokdad AH¹
Murray CJL¹
Plass D¹⁹
Rana S^{20, 21}
Rein DB²²
Richardus JH²³
Sanabria J^{24, 25}
Saylan M²⁶
Shahraz S²⁷
So S²⁸
Vlassov VV²⁹
Weiderpass E^{30, 31, 32, 33}
Wiersma ST³⁴
Younis M³⁵
Yu C³⁶
El Sayed Zaki M³⁷
Cooke GS³⁸

Show Affiliations

1. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States
2. Division of Hematology, Department of Medicine, University of Washington, Seattle, WA, United States
3. Institute for Global Health, University College London, London, United Kingdom
4. Infectious Disease Epidemiology Group, Weill Cornell Medicineâ€”Qatar, Qatar Foundation, Doha, Qatar
5. Mashhad University of Medical Sciences, Mashhad, Iran
6. Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
7. University of Otago Medical School, Wellington, New Zealand
8. WHO Collaborating Centre for Viral Hepatitis, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, Australia
9. Doherty Institute, University of Melbourne, Melbourne, VIC, Australia
10. Johns Hopkins Bayview Medical Center, Baltimore, MD, United States
11. Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia
12. School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
13. Department of Global and Community Health, George Mason University, Fairfax, VA, United States
14. Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH, United States
15. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
16. Division of Global Public Health, University of California San Diego, San Diego, CA, United States
17. School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
18. Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States
19. Section Exposure Assessment and Environmental Health Indicators, Federal Environmental Agency, Berlin, Germany
20. Contech School of Public Health, Lahore, Pakistan
21. Contech International Health Consultants, Lahore, Pakistan
22. NORC at the University of Chicago, Chicago, IL, United States
23. Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
24. Case Western Reserve University, Cleveland, OH, United States
25. Cancer Treatment Centers of America, Rosalind Franklin University Chicago Medical School, North Chicago, IL, United States
26. Bayer AG Turkey, Fatih Sultan Mehmet Mah Balkan Cad, Istanbul, Turkey
27. Tufts Medical Center, Boston, MA, United States
28. Asian Liver Center, Stanford University School of Medicine, Palo Alto, CA, United States
29. National Research University Higher School of Economics, Moscow, Russian Federation
30. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
31. Department of Research, Cancer Registry of Norway, Oslo, Norway
32. Department of Community Medicine, Faculty of Health Sciences, University of Tromsoâ€”The Arctic University of Norway, Tromso, Norway
33. Genetic Epidemiology Group, Folkhalsan Research Center, University of Helsinki, Helsinki, Finland
34. US Centers for Disease Control and Prevention, Kampala, Uganda
35. Jackson State University, Jackson, MS, United States
36. Department of Epidemiology and Biostatistics, School of Public Health, and Global Health Institute, Wuhan University, Wuhan, Hubei, China
37. Faculty of Medicine, Mansoura University, Mansoura, Egypt
38. Division of Infectious Diseases, Imperial College, London, United Kingdom

Source: The Lancet Published:2016

Abstract

Background With recent improvements in vaccines and treatments against viral hepatitis, an improved understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We used data from the Global Burden of Disease (GBD) Study to estimate morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer caused by viral hepatitis, by age, sex, and country from 1990 to 2013. Methods We estimated mortality using natural history models for acute hepatitis infections and GBD's cause-of-death ensemble model for cirrhosis and liver cancer. We used meta-regression to estimate total cirrhosis and total liver cancer prevalence, as well as the proportion of cirrhosis and liver cancer attributable to each cause. We then estimated cause-specific prevalence as the product of the total prevalence and the proportion attributable to a specific cause. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost (YLLs) and years lived with disability (YLDs). Findings Between 1990 and 2013, global viral hepatitis deaths increased from 0·89 million (95% uncertainty interval [UI] 0·86–0·94) to 1·45 million (1·38–1·54); YLLs from 31·0 million (29·6–32·6) to 41·6 million (39·1–44·7); YLDs from 0·65 million (0·45–0·89) to 0·87 million (0·61–1·18); and DALYs from 31·7 million (30·2–33·3) to 42·5 million (39·9–45·6). In 2013, viral hepatitis was the seventh (95% UI seventh to eighth) leading cause of death worldwide, compared with tenth (tenth to 12th) in 1990. Interpretation Viral hepatitis is a leading cause of death and disability worldwide. Unlike most communicable diseases, the absolute burden and relative rank of viral hepatitis increased between 1990 and 2013. The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health. Funding Bill & Melinda Gates Foundation. © 2016 Elsevier Ltd

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Style	Citing Format
MLA	Stanaway JD, et al.. "The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013." The Lancet, vol. 388, no. 10049, 2016, pp. 1081-1088.
APA	Stanaway JD, Flaxman AD, Naghavi M, Fitzmaurice C, Vos T, Abubakar I, Aburaddad LJ, Assadi R, Bhala N, Cowie B, Forouzanfour MH, Groeger J, Hanafiah KM, Jacobsen KH, James SL, Maclachlan J, Malekzadeh R, Martin NK, Mokdad AA, ... Cooke GS (2016). The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013. The Lancet, 388(10049), 1081-1088.
Chicago	Stanaway JD, Flaxman AD, Naghavi M, Fitzmaurice C, Vos T, Abubakar I, Aburaddad LJ, et al.. "The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013." The Lancet 388, no. 10049 (2016): 1081-1088.
Harvard	Stanaway JD et al. (2016) 'The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013', The Lancet, 388(10049), pp. 1081-1088.
Vancouver	Stanaway JD, Flaxman AD, Naghavi M, Fitzmaurice C, Vos T, Abubakar I, et al.. The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013. The Lancet. 2016;388(10049):1081-1088.
BibTex	@article{ author = {Stanaway JD and Flaxman AD and Naghavi M and Fitzmaurice C and Vos T and Abubakar I and Aburaddad LJ and Assadi R and Bhala N and Cowie B and Forouzanfour MH and Groeger J and Hanafiah KM and Jacobsen KH and James SL and Maclachlan J and Malekzadeh R and Martin NK and Mokdad AA and Mokdad AH and Murray CJL and Plass D and Rana S and Rein DB and Richardus JH and Sanabria J and Saylan M and Shahraz S and So S and Vlassov VV and Weiderpass E and Wiersma ST and Younis M and Yu C and El Sayed Zaki M and Cooke GS}, title = {The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013}, journal = {The Lancet}, volume = {388}, number = {10049}, pages = {1081-1088}, year = {2016} }
RIS	TY - JOUR AU - Stanaway JD AU - Flaxman AD AU - Naghavi M AU - Fitzmaurice C AU - Vos T AU - Abubakar I AU - Aburaddad LJ AU - Assadi R AU - Bhala N AU - Cowie B AU - Forouzanfour MH AU - Groeger J AU - Hanafiah KM AU - Jacobsen KH AU - James SL AU - Maclachlan J AU - Malekzadeh R AU - Martin NK AU - Mokdad AA AU - Mokdad AH AU - Murray CJL AU - Plass D AU - Rana S AU - Rein DB AU - Richardus JH AU - Sanabria J AU - Saylan M AU - Shahraz S AU - So S AU - Vlassov VV AU - Weiderpass E AU - Wiersma ST AU - Younis M AU - Yu C AU - El Sayed Zaki M AU - Cooke GS TI - The Global Burden of Viral Hepatitis From 1990 to 2013: Findings From the Global Burden of Disease Study 2013 JO - The Lancet VL - 388 IS - 10049 SP - 1081 EP - 1088 PY - 2016 ER -

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