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Global Prevalence, Cascade of Care, and Prophylaxis Coverage of Hepatitis B in 2022: A Modelling Study Publisher Pubmed



Razavishearer DM1 ; Gamkrelidze I1 ; Pan CQ2 ; Jia J3 ; Berg T4 ; Gray RT5 ; Lim YS6 ; Chen CJ7 ; Ocama P8 ; Desalegn H9 ; Abbas Z10 ; Abdallah AR11, 12 ; Aghemo A13, 14 ; Ahmadbekova S15 Show All Authors
Authors
  1. Razavishearer DM1
  2. Gamkrelidze I1
  3. Pan CQ2
  4. Jia J3
  5. Berg T4
  6. Gray RT5
  7. Lim YS6
  8. Chen CJ7
  9. Ocama P8
  10. Desalegn H9
  11. Abbas Z10
  12. Abdallah AR11, 12
  13. Aghemo A13, 14
  14. Ahmadbekova S15
  15. Ahn SH16
  16. Aho I17
  17. Akarca US18
  18. Al Masri NM19
  19. Alalwan AM20
  20. Alavian SM21
  21. Albusafi SA22
  22. Aleman S23
  23. Alfaleh FZ24
  24. Alghamdi AS25
  25. Alhamoudi WK26
  26. Aljumah AA27
  27. Alnaamani K28
  28. Alrifai A29
  29. Alserkal YM30
  30. Altraif IH31
  31. Amarsanaa J32
  32. Anderson M33
  33. Andersson MI34
  34. Armstrong P35
  35. Asselah T36
  36. Athanasakis K37
  37. Baatarkhuu O38
  38. Benari Z39, 40
  39. Bensalem A41
  40. Bessone F42
  41. Biondi MJ43
  42. Bizri ARN44
  43. Blach S1
  44. Braga WSM45
  45. Brandaomello CE46, 47
  46. Brosgart CL48
  47. Brown KA49
  48. Bruggmann P51
  49. Brunetto MR52, 53
  50. Buti M54
  51. Cabezas J55, 56
  52. Casanovas T57
  53. Chae C58
  54. Chan HLY59
  55. Cheinquer H60
  56. Chen PJ61
  57. Cheng KJG62
  58. Cheon ME63
  59. Chien CH64
  60. Choudhuri G65
  61. Christensen PB66, 67
  62. Chuang WL68
  63. Chulanov V69
  64. Cisneros Garza LE70
  65. Coffin CS71
  66. Contreras FA72
  67. Coppola N73
  68. Cornberg M74
  69. Cowie B75
  70. Cramp ME76
  71. Craxi A77
  72. Crespo J78, 79
  73. Cui F80
  74. Cunningham CW81
  75. Dalgard O82
  76. De Knegt RJ83
  77. De Ledinghen V84
  78. Dore GJ5
  79. Drazilova S85
  80. Duberg AS86
  81. Egeonu S87
  82. Elbadri M88
  83. Elkassas M89
  84. Elsayed MH90
  85. Estes C1
  86. Etzion O91, 92
  87. Farag E93
  88. Ferradini L94
  89. Ferreira PRA95
  90. Flisiak R96
  91. Forns X97
  92. Frankova S98
  93. Fung J99
  94. Gane EJ100
  95. Garcia V101, 102, 103
  96. Garciasamaniego J104
  97. Gemilyan M105
  98. Genov J106
  99. Gheorghe LS107, 108
  100. Gholam PM109
  101. Gish RG110
  102. Goleij P111
  103. Gottfredsson M112, 113
  104. Grebely J5
  105. Gschwantler M114, 115
  106. Guingane NA116
  107. Hajarizadeh B5
  108. Hamid SS117
  109. Hamoudi W118
  110. Harris AM119
  111. Hasan I120
  112. Hatzakis A121
  113. Hellard ME122
  114. Hercun J123
  115. Hernandez J124
  116. Hockickova I125, 147
  117. Hsu YC126
  118. Hu CC127
  119. Husa P128, 129
  120. Janicko M85
  121. Janjua N130
  122. Jarcuska P85
  123. Jaroszewicz J131
  124. Jelev D132
  125. Jeruma A133, 134
  126. Johannessen A135
  127. Kaberg M136
  128. Kaita KDE137
  129. Kaliaskarova KS138
  130. Kao JH139
  131. Kellyhanku A5
  132. Khamis F140
  133. Khan AG141
  134. Kheir OO142
  135. Khoudri I143
  136. Kondili LA144, 145
  137. Konysbekova A146
  138. Kristian P125, 147
  139. Kwon JA5
  140. Lagging M148, 149
  141. Laleman W150, 151
  142. Lampertico P152
  143. Lavanchy D153
  144. Lazaro P154
  145. Lazarus JV155
  146. Lee AU156
  147. Lee MH157
  148. Liakina V158, 159
  149. Luksic B160
  150. Malekzadeh R161
  151. Malu AO162, 163
  152. Marinho RT164
  153. Mendescorrea MC165
  154. Merat S166
  155. Meshesha BR9
  156. Midgard H167
  157. Mohamed R168
  158. Mokhbat JE169
  159. Mooneyhan E1
  160. Moreno C170
  161. Mortgat L171
  162. Mullhaupt B172
  163. Musabaev E173
  164. Muyldermans G171
  165. Naveira MCM1
  166. Negro F174
  167. Nersesov AV175
  168. Nguyen VTT176
  169. Ning Q177, 178
  170. Njouom R179
  171. Ntagirabiri R180
  172. Nurmatov ZS181
  173. Oguche S182
  174. Omuemu CE183
  175. Ong JP184
  176. Oparesem OK185
  177. Ormeci N186
  178. Orrego M187, 188
  179. Osiowy C189
  180. Papatheodoridis GV190
  181. Peckradosavljevic M191
  182. Pessoa MG192
  183. Pham TND193
  184. Phillips RO194
  185. Pimenov N195
  186. Pincayrodriguez LDR196
  187. Plaseskakaranfilska D197
  188. Pop C198
  189. Poustchi H166
  190. Prabdialsing NN199
  191. Qureshi H200
  192. Ramji A201
  193. Rautiainen H202
  194. Razavishearer K1
  195. Remak WM203
  196. Ribeiro S204
  197. Ridruejo E205
  198. Rioshincapie CY206
  199. Robalino MC207
  200. Roberts LR208
  201. Roberts SK209
  202. Rodriguez M210
  203. Roulot D211
  204. Rwegasha J212
  205. Ryder SD213
  206. Sadirova S214
  207. Saeed U215, 216
  208. Safadi R217
  209. Sagalova O218
  210. Said SS219
  211. Salupere R220, 221
  212. Sanai FM222
  213. Sanchezavila JF223
  214. Saraswat VA224
  215. Sargsyants N225
  216. Sarrazin C226, 227
  217. Sarybayeva G228
  218. Schreter I229
  219. Seguindevaux C230
  220. Seto WK231, 232
  221. Shah SR233
  222. Sharara AI44
  223. Sheikh M166
  224. Shouval D217
  225. Sievert W234
  226. Simojoki K235
  227. Simonova MY236
  228. Sinn DH237
  229. Sonderup MW238
  230. Sonneveld MJ239
  231. Spearman CW238
  232. Sperl J98
  233. Stauber RE240
  234. Stedman CAM241
  235. Sypsa V242
  236. Tacke F243
  237. Tan SS244
  238. Tanaka J245
  239. Tergast TL74
  240. Terrault NA246
  241. Thompson AJ247
  242. Thompson PJ248
  243. Tolmane I249, 250
  244. Tomasiewicz K251
  245. Tsang TY252
  246. Uzochukwu BSC253, 254, 255
  247. Van Welzen B256
  248. Vanwolleghem T257
  249. Vince A258
  250. Voeller AS1
  251. Waheed Y259, 260
  252. Waked I261
  253. Wallace J262, 263, 264
  254. Wang C265
  255. Weis N266, 267
  256. Wong GLH268
  257. Wong VWS268
  258. Wu JC269, 270
  259. Yaghi CG271
  260. Yesmembetov K138, 272
  261. Yip TCF268
  262. Yosry A273
  263. Yu ML274, 275, 276
  264. Yuen MF277
  265. Yurdaydin C278
  266. Zeuzem S279
  267. Zuckerman E280
  268. Razavi HA1

Source: The Lancet Gastroenterology and Hepatology Published:2023


Abstract

Background: The 2016 World Health Assembly endorsed the elimination of hepatitis B virus (HBV) infection as a public health threat by 2030; existing therapies and prophylaxis measures make such elimination feasible, even in the absence of a virological cure. We aimed to estimate the national, regional, and global prevalence of HBV in the general population and among children aged 5 years and younger, as well as the rates of diagnosis, treatment, prophylaxis, and the future burden globally. Methods: In this modelling study, we used a Delphi process with data from literature reviews and interviews with country experts to quantify the prevalence, diagnosis, treatment, and prevention measures for HBV infection. The PRoGReSs Model, a dynamic Markov model, was used to estimate the country, regional, and global prevalence of HBV infection in 2022, and the effects of treatment and prevention on disease burden. The future incidence of morbidity and mortality in the absence of additional interventions was also estimated at the global level. Findings: We developed models for 170 countries which resulted in an estimated global prevalence of HBV infection in 2022 of 3·2% (95% uncertainty interval 2·7–4·0), corresponding to 257·5 million (216·6–316·4) individuals positive for HBsAg. Of these individuals, 36·0 million were diagnosed, and only 6·8 million of the estimated 83·3 million eligible for treatment were on treatment. The prevalence among children aged 5 years or younger was estimated to be 0·7% (0·6–1·0), corresponding to 5·6 million (4·5–7·8) children with HBV infection. Based on the most recent data, 85% of infants received three-dose HBV vaccination before 1 year of age, 46% had received a timely birth dose of vaccine, and 14% received hepatitis B immunoglobulin along with the full vaccination regimen. 3% of mothers with a high HBV viral load received antiviral treatment to reduce mother-to-child transmission. Interpretation: As 2030 approaches, the elimination targets remain out of reach for many countries under the current frameworks. Although prevention measures have had the most success, there is a need to increase these efforts and to increase diagnosis and treatment to work towards the elimination goals. Funding: John C Martin Foundation, Gilead Sciences, and EndHep2030. © 2023 Elsevier Ltd
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