Peg1000 As a Low Melting and Ecofriendly Solvent for Air Oxidative and Catalyst Free 2,4-Disubstitute Quinazoline Synthesis Publisher



Moghadam ES¹ ; Ghafary S¹ ; Amini M¹ Show Affiliations
Source: Letters in Organic Chemistry Published:2020

Abstract

With regard to the importance of quinazoline as a privileged scaffold, herein we report the synthesis of twenty seven 2,4-disubstitute quinazoline derivatives in a new catalyst free condition. In the current work, poly ethylene glycol (PEG1000) as an inexpensive, very simple commercially available, ecofriendly and low melting point solvent was used. Air bubbling, a green oxidant, for oxidation purpose was also used. This is the first report about using PEG1000 as a solvent simultaneously with air bubbling as oxidant in quinazoline synthesis. All of the compounds 1-27 were synthesized in high yield with very simple work up and purification process without using column chromatography. All the structures were confirmed using1 H NMR,13 C NMR, IR, MS and elemental analysis. © 2020, Bentham Science Publishers. All rights reserved.