Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Recent Advances in the Use of 2-Aminobenzyl Alcohols in the Synthesis of Quinolines, Quinazolines and Other N-Heterocycles Publisher



Doraghi F1 ; Gilaninezhad F2 ; Karimian S3 ; Mahdavian AM1 ; Larijani B1 ; Mahdavi M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713119, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, 1417614411, Iran
  3. 3. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, 7134853734, Iran

Source: Advanced Synthesis and Catalysis Published:2024


Abstract

N-Heterocyclic compounds, in particular, quinolines and quinazolines are frequently used in medicinal chemistry. Therefore, the direct and clean synthesis of these valuable scaffolds has been a great interest for many years. 2-Aminobenzyl alcohols as an alternative reactant instead of unstable and expensive 2-aminobenzaldehydes can be used in the construction of N-fused heterocycles including quinolines, quinazolines, oxazines, thiazines, selenazines, imidazoles, diazepines, etc. In this review article, we have discussed recent developments in the use of 2-aminobenzyl alcohols in the synthesis of diverse heterocycles. © 2024 Wiley-VCH GmbH.