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Role of Exosome in Autoimmunity, With a Particular Emphasis on Rheumatoid Arthritis Publisher Pubmed



Hejrati A1 ; Hasani B2, 3 ; Esmaili M2, 3 ; Bashash D4 ; Tavakolinia N5 ; Zafari P2, 3
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Hazrate-Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Rheumatic Diseases Published:2021


Abstract

Cell-derived exosomes are identified as carriers of lipids, proteins, and genetic materials that participate in cell-cell signal communication, biological process, and cell signaling. Also, their involvement has been reported in a vast array of disorders and inflammatory conditions such as autoimmune diseases. Rheumatoid arthritis (RA), a common cause of joint disorder, is an inflammation-based disease in which the precise understanding of its pathogenesis needs to be further investigated. Also, there is only a palliative care approach for the alleviation of RA symptoms. This paper discusses the recent advances in the biology of exosomes in autoimmune disorders especially in RA, and also provides a new line of research for arthritis therapy using exosomes. © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
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