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Association of Nesfatin-1 Level With Body Composition, Dietary Intake and Resting Metabolic Rate in Obese and Morbid Obese Subjects Publisher Pubmed



Mirzaei K1 ; Hosseinnezhad A2, 3 ; Keshavarz SA4 ; Koohdani F1 ; Eshraghian MR5 ; Sabooryaraghi AA1 ; Hosseini S4 ; Chamari M1 ; Zareei M1 ; Djalali M1
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Nutrition Department, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, United States
  4. 4. Clinical Nutrition Department, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Statistics, School of Public Health, Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2015


Abstract

Aims Nesfatin-1 identified neuroendocrine peptide is involved in regulation of homeostasis via modulation of metabolism, energy homeostasis and food intake. We aimed to investigate the associations of circulating nesfatin-1 level with food intake, body composition and resting metabolic rate (RMR) and also examine the correlation between circulating peroxisome proliferator-activated receptor gamma (PPARγ) and nesfatin-1 levels in obese and morbid obese subjects. Methods A total of 96 obese subjects (including 18 morbid obese subjects) were participated in the current cross-sectional study. We assessed the body composition with the use of Body Composition Analyzer. RMR was measured by means of the MetaCheck™, an instrument designed to measure RMR using indirect calorimetry. All baseline blood samples were obtained following an overnight fasting. Plasma concentrations of nesfatin-1 and circulating PPARγ were measured with the use of an ELISA method. Statistical analyses were performed using SPSS. Results We found significant associations between fat percent and circulating nesfatin-1 in obese and morbid obese subjects. There was main association between circulating nesfatin-1 and PPARγ concentration in obese subjects and it was more strong association in morbid obese participants. There was marginally significant differences between percent predicted RMR between different categorized nesfatin-1 levels. There were also higher intakes of calorie, carbohydrate and protein in obese group who had lower concentration of nesfatin-1. Conclusions Our data indicated the fat percent as main determinant factor in circulating nesfatin-1 level. It appears nesfatin-1 and PPARγ might be concurrently involved in adipogenesis pathway. © 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.
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