Association of Nesfatin-1 Level With Body Composition, Dietary Intake and Resting Metabolic Rate in Obese and Morbid Obese Subjects Publisher Pubmed



Mirzaei K¹ ; Hosseinnezhad A^{2, 3} ; Keshavarz SA⁴ ; Koohdani F¹ ; Eshraghian MR⁵ ; Sabooryaraghi AA¹ ; Hosseini S⁴ ; Chamari M¹ ; Zareei M¹ ; Djalali M¹
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2015

Abstract

Aims Nesfatin-1 identified neuroendocrine peptide is involved in regulation of homeostasis via modulation of metabolism, energy homeostasis and food intake. We aimed to investigate the associations of circulating nesfatin-1 level with food intake, body composition and resting metabolic rate (RMR) and also examine the correlation between circulating peroxisome proliferator-activated receptor gamma (PPARγ) and nesfatin-1 levels in obese and morbid obese subjects. Methods A total of 96 obese subjects (including 18 morbid obese subjects) were participated in the current cross-sectional study. We assessed the body composition with the use of Body Composition Analyzer. RMR was measured by means of the MetaCheck™, an instrument designed to measure RMR using indirect calorimetry. All baseline blood samples were obtained following an overnight fasting. Plasma concentrations of nesfatin-1 and circulating PPARγ were measured with the use of an ELISA method. Statistical analyses were performed using SPSS. Results We found significant associations between fat percent and circulating nesfatin-1 in obese and morbid obese subjects. There was main association between circulating nesfatin-1 and PPARγ concentration in obese subjects and it was more strong association in morbid obese participants. There was marginally significant differences between percent predicted RMR between different categorized nesfatin-1 levels. There were also higher intakes of calorie, carbohydrate and protein in obese group who had lower concentration of nesfatin-1. Conclusions Our data indicated the fat percent as main determinant factor in circulating nesfatin-1 level. It appears nesfatin-1 and PPARγ might be concurrently involved in adipogenesis pathway. © 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.