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Coagulopathy and Thromboembolic Events a Pathogenic Mechanism of Covid-19 Associated With Mortality: An Updated Review Publisher Pubmed



Yousefi P1 ; Soltani S2 ; Siri G3 ; Rezayat SA4 ; Gholami A5 ; Zafarani A6 ; Razizadeh MH1 ; Alborzi E1 ; Mokhtaryirani G7 ; Abedi B8 ; Karampoor S1, 9 ; Tabibzadeh A1 ; Farahani A8, 10
Authors

Source: Journal of Clinical Laboratory Analysis Published:2023


Abstract

During 2019, the SARS-CoV-2 emerged from China, and during months, COVID-19 spread in many countries around the world. The expanding data about pathogenesis of this virus could elucidate the exact mechanism by which COVID-19 caused death in humans. One of the pathogenic mechanisms of this disease is coagulation. Coagulation disorders that affect both venous and arterial systems occur in patients with COVID-19. The possible mechanism involved in the coagulation could be excessive inflammation induced by SARS-CoV-2. However, it is not yet clear well how SARS-CoV-2 promotes coagulopathy. However, some factors, such as pulmonary endothelial cell damage and some anticoagulant system disorders, are assumed to have an important role. In this study, we assessed conducted studies about COVID-19-induced coagulopathy to obtain clearer vision of the wide range of manifestations and possible pathogenesis mechanisms. © 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
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