Coagulopathy and Thromboembolic Events a Pathogenic Mechanism of Covid-19 Associated With Mortality: An Updated Review Publisher Pubmed



Yousefi P¹ ; Soltani S² ; Siri G³ ; Rezayat SA⁴ ; Gholami A⁵ ; Zafarani A⁶ ; Razizadeh MH¹ ; Alborzi E¹ ; Mokhtaryirani G⁷ ; Abedi B⁸ ; Karampoor S^{1, 9} ; Tabibzadeh A¹ ; Farahani A^{8, 10} Show Affiliations
Source: Journal of Clinical Laboratory Analysis Published:2023

Abstract

During 2019, the SARS-CoV-2 emerged from China, and during months, COVID-19 spread in many countries around the world. The expanding data about pathogenesis of this virus could elucidate the exact mechanism by which COVID-19 caused death in humans. One of the pathogenic mechanisms of this disease is coagulation. Coagulation disorders that affect both venous and arterial systems occur in patients with COVID-19. The possible mechanism involved in the coagulation could be excessive inflammation induced by SARS-CoV-2. However, it is not yet clear well how SARS-CoV-2 promotes coagulopathy. However, some factors, such as pulmonary endothelial cell damage and some anticoagulant system disorders, are assumed to have an important role. In this study, we assessed conducted studies about COVID-19-induced coagulopathy to obtain clearer vision of the wide range of manifestations and possible pathogenesis mechanisms. © 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.