Exosome Biosensors for the Detection of Breast Cancer Publisher Pubmed



Mh Sadeghi Mohammad HASSAN ; N Kheradi NILOUFAR ; S Nazem SHIMA ; S Amirsaadat SOUMAYEH ; M Ashourpour MARYAM ; S Aghakhani Chegeni SARA ; S Sohrabi SEPIDEH ; M Zamani Sani MARYAM ; A Movahedpour AHMAD ; E Norouz Dolatabadi ELHAM
Source: Clinica Chimica Acta Published:2025

Abstract

Breast cancer, the most common malignancy in women, is difficult to identify early with conventional techniques like biopsy and mammography, which are frequently invasive and prone to false negative results. Exosome-based detection is a novel, non-invasive diagnostic technique made possible by recent developments in biosensor technology. Exosomes, which are tiny extracellular vesicles released by cells, include biomarkers including microRNAs and oncogenic proteins that offer vital information about the occurrence and spread of breast cancer. By identifying exosomal biomarkers, biosensors use high sensitivity, specificity, and real-time analysis to facilitate early cancer detection, individualized treatment plans, and better patient outcomes. This review explores the biology of exosomes and their roles in intercellular communication, cancer progression, and therapeutic potential. It further examines the development and application of electrochemical, optical, and electrical biosensors for the detection of breast cancer-derived exosomes. © 2025 Elsevier B.V., All rights reserved.