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Current Understanding of Therapeutic and Diagnostic Applications of Exosomes in Pancreatic Cancer Publisher Pubmed



Shakerian N1 ; Tafazoli A2 ; Razavinia A3 ; Aghajani ZS4 ; Bana N5 ; Mardsoltani M1 ; Khalesi B6 ; Hashemi ZS7, 9 ; Khalili S8
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical Sciences, Dezful, Iran
  2. 2. Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  4. 4. Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran
  5. 5. University of Teheran, Kish International Campus, Iran
  6. 6. Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran
  7. 7. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  8. 8. Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
  9. 9. Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, No 146, South Gandhi Ave, Vanak Squire, Tehran, 009821, Iran

Source: Pancreas Published:2025


Abstract

Unusual symptoms, rapid progression, lack of reliable early diagnostic biomarkers, and lack of efficient treatment choices are the ongoing challenges of pancreatic cancer. Numerous research studies have demonstrated the correlation between exosomes and various aspects of pancreatic cancer. In light of these facts, exosomes possess the potential to play functional roles in the treatment, prognosis, and diagnosis of the pancreatic cancer. In the present study, we reviewed the most recent developments in approaches for exosome separation, modification, monitoring, and communication. Moreover, we discussed the clinical uses of exosomes as less invasive liquid biopsies and drug carriers and their contribution to the control of angiogenic activity of pancreatic cancer. Better investigation of exosome biology would help to effectively engineer therapeutic exosomes with certain nucleic acids, proteins, and even exogenous drugs as their cargo. Circulating exosomes have shown promise as reliable candidates for pancreatic cancer early diagnosis and monitoring in high-risk people without clinical cancer manifestation. Although we have tried to reflect the status of exosome applications in the treatment and detection of pancreatic cancer, it is evident that further studies and clinical trials are required before exosomes may be employed as a routine therapeutic and diagnostic tools for pancreatic cancer. © 2024 Wolters Kluwer Health, Inc. All rights reserved.
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